Week 10 - Rec and Perform Drugs - Analgesics - Nociception Flashcards
1
Q
What are types of painful stimulations?
A
Nociception - noxious stimulant
Neuropathic Pain - nerve pain,diabetes
Hyperalgesia / Allodynia
-perceived noxious stimulant
2
Q
What are the stimuli of Nociception?
A
Chemical
Mechanical
Thermal
3
Q
What are some chemical stimuli for nociception?
A
- Kinins
- Prostaglandins
- 5-HT
- Histamine
4
Q
What are the mechanisms of Nociception transmission?
A
- Enters the spinal cord via the doral roots
- Afferent neurons release glutamate and ATP as neuromodulators
- Brain lesions in medial thalamus can cause analgesia
5
Q
Which fibres are responsible for nociception?
And what are their characteristics?
A
A and C
Terminate in superficial region
Some penetrate deeper into dorsal horn
Heavily populated by opioid receptors
6
Q
What are the characteristics of A fibres?
A
- myelinated
- sharp well localised pain
- fast transmission - mechanical
7
Q
What are the characteristics of C fibres?
A
-unmyelinated
-dull burning pain
slow transmision - swelling
