Week 6- Injury and Healing Flashcards
What are the 3 mechanisms of bone fracture?
Trauma (low energy or high energy)
Stress (abnormal stress on normal bone)
Pathological (normal stress on abnormal bone)
What are the different types of fractures?
Simple/closed Open Transverse Spiral Impacted Greenstick and torus Comminuted
What needs to be described when diagnosing a fracture?
Soft tissue integrity: is it open or closed
Bony fragments: is it greenstick, simple or comminuted
Displacement: is the bone displaced or undisplaced
How do stress fractures arise?
Overuse leads to stress exerted on bone greater than the bones capacity to remodel, this causes the bone to weaken and can lead to a stress fracture
What groups of people are at risk of stress fractures?
Athletes, military personnel, female athlete triad
What bones are at risk of being affected by stress fractures?
Weight baring bones eg tibia, metatarsals, navicular
What is female athletes triad?
Disordered eating (calorie deficit)
Amenorrhea (due to high weight loss)
Osteoporosis (bigger holes make them prone to fracture)
What may be pathological causes of fracture?
Osteoporosis (soft bone) Malignancy (primary or bone metastases) Vit D deficiency (osteomalacia or rickets) Osteomyelitis (infection of the bone) Osteogenesis imperfecta Paget’s disease
Who is typically likely to develop a vit D deficiency?
People with darker skin who dont get much sun
What is the stage before osteoporosis?
Osteopenia (thinning of the bone)
Why may someone develop osteoporosis?
Osteoclast activity> osteoblast activity
Is osteoporosis more common in males or females?
Females
What are fractures associated with osteoporosis called? Where do they most commonly occour?
Fragility fractures (in hips, spine and wrist)
What are the 5 main cancers that metastasise to bone?
Prostate (blastic) Breast (blastic or lytic) Lytic: Kidney Thyroid Lung
What is the difference between a blastic and a lytic cancer?
Blastic: cancer cells fill the organ
Lytic: cancer cells cause destruction of cells in organ
What are the 4 primary bone cancers?
Osteosarcoma
Chondrosarcoma
Ewing sarcoma
Chordoma
What is osteogenesis imperfecta?
Brittle bone disease, type 1 collagen decreases due to decreased secretion and production of abnormal collagen resulting in insufficient osteoid production
How is osteogenesis imperfecta inherited?
Autosomal dominant or recessive
What is Paget’s disease?
Excessive bone break down and disorganised remodelling leading to deformity, pain, fracture and arthritis, can transform into a malignant disease
What are the 4 stages of Paget’s disease?
Osteoclastic activity
Mixed osteoclastic/osteoblastic activity
Osteoblastic activity
Malignant degeneration