WBC Disorders

Question 1

Lymphoma vs Leukemia?

Answer 1

Lymphoma - malignant proliferations of lymph tissue that produce tumor

Leukemia - Malignant cells of bone marrow that spill into the peripheral blood

Question 2

What is Hodgkin Lymphoma?

Answer 2

A lymphoma of a distinctive cell type (Reed-Sternberg cell) that arises in a single lymph node

Highly curable

Question 3

What ages are most likely to get Hodgkin Lymphoma?

Answer 3

20-30 yrs old or over 50

Question 4

T/F: Hodgkin Lymphoma presents with a painful lymphadenopathy.

Answer 4

FALSE

Tumor is painless

Question 5

What is present in 70% of Reed-Sternberg cells?

Answer 5

Epstein-Barr virus

Question 6

What is needed for diagnosis of Hodgkin Lymphoma?

Answer 6

Biopsy of lymph node and identification of RS cell in appropriate background

Question 7

What is the origin of a RS cell?

Answer 7

Germinal center B lymphocyte

Question 8

What is the stage of a Hodgkin lymphoma that is on both sides of the diaphragm?

Answer 8

Stage III

Question 9

What is needed to be a stage IV Hodgkin lymphoma?

Answer 9

Tumor in organs other than lymph nodes, spleen, or Waldeyer’s ring

Question 10

Describe a tumor that is Stage II B?

Answer 10

Tumor is in more than two anatomic regions but on the same side of the diaphragm.

B = clinical symptoms are seen (fever, night sweats, weight loss)

Question 11

T/F: Most non-hodgkin lymphomas are of B cell origin.

Answer 11

True

Question 12

What age group is most likely to get NHL?

Answer 12

Over 40

Question 13

T/F: Hodgkin lymphoma is more common than NHL?

Answer 13

FALSE

Question 14

T/F: Nodular NHL disease has better prognosis than diffuse NHL disease.

Answer 14

True

Question 15

T/F: Small cell NHL is better than large cell NHL.

Answer 15

True

Question 16

What constitutes for high stage NHL?

Answer 16

Numerous sites of involvement or bone marrow involvement

Question 17

What makes prognosis of NHL different than other cancers?

Answer 17

Grading or sub-typing is more important than staging

Question 18

What are the characteristics of acute leukemia?

Answer 18

1. Rapid onset with blasts in blood

2. Myeloid and lymphoid cells affected

Question 19

What are the characteristics of chronic leukemia?

Answer 19

1. Indolent onset and involves mature cells

2. Myeloid and lymphoid cells affected

Question 20

What is the major difference in cell types between acute and chronic leukemia?

Answer 20

Acute involves blast cells while chronic involves mature cells

Question 21

What is the most frequent cancer in children < 15 years old?

Answer 21

Acute lymphoblastic leukemia

Question 22

For those with acute lymphoblastic leukemia, children have a ______ prognosis, while adults have a ______ prognosis.

Answer 22

Good; bad

Question 23

What is the treatment for acute lymphoblastic leukemia?

Answer 23

Chemotherapy with possible bone marrow transplant at relapse

Question 24

In acute myelogenous leukemia involves an increased WBC count, often accompanied by ___________ and ____________.

Answer 24

Anemia; thrombocytopenia

Question 25

T/F: Acute myelogenous leukemia is more common in children.

Answer 25

FALSE

Adults

Question 26

Chronic lymphocytic leukemia expresses surface _____ and high expression of _______.

Answer 26

IgM; BCL2

Question 27

What is the most common adult leukemia in the US?

Answer 27

Chronic lymphocytic leukemia

Question 28

Chronic lymphocytic leukemia often presents with ____________ and ____________.

Answer 28

Splenomegaly; lymphadenopathy

Question 29

In chronic lymphocytic leukemia, tumor cells suppress normal B cells, leading to __________.

Answer 29

Hypogammaglobulinemia

Question 30

Chronic myelogenous leukemia is a _______ cell disorder.

Answer 30

Stem