Thrombosis, Shock Flashcards
What is a thrombus?
An intravascular clot
What are the three points to Virchow’s triad?
- Endothelial injury
- Alterations in blood flow
- Hypercoagulabiltiy
What do the three points of Virchow’s triangle lead to?
Thrombosis
What genetic factors can lead to hypercoagulability?
- Factor V Leiden
- Prothrombin mutation
- AT III deficiency
What are some acquired condition that can lead to hypercoagulability?
- Bed rest
- Extensive tissue injury
- Pregnancy
- Cancer
Where is thrombosis most likely to occur?
Deep vein thrombosis
If distinct lines of Zahn are seen during thrombosis, what type of vessel is the site of the problem?
Arteries
What is Disseminated Intravascular Coagulation (DIC)?
Widespread activation of coagulation cascade - causes potential bleeding due to overconsumption of clotting material in one area
What is the most common type of embolus?
A thrombosis dislodging from a vein
T/F: All pulmonary thromboembolisms cause clinical problems?
FALSE
Where does a systemic embolization typically originate?
Walls of the heart
What is an infarction?
Blockage of a vessel leads to necrosis of tissue
Red infarction is often associated with ________ tissue, while white infarction is often associated with ________ tissue.
Venous; arterial
What is shock?
Systemic hypoperfusion: inability to get blood through the system
What are the different types of shock?
Cardiogenic: heart cant push blood
Hypovolemic: not enough blood
Septic: involved with disease
