Musculoskeletal Flashcards
Function of the osteoblast bound RANK ligand with the osteoclasts bound RANK receptor has what affect on the osteoclasts?
Promotes osteoclasts function/differentiation
What is the function of osteoprotegerin?
Blocks RANK ligand/receptor binding and therefore inhibits osteoclasts function
T/F: IL-1 and TNF-alpha stimulate osteoclasts activity.
True
Osteogenesis Imperfecta is a hereditary disorder that causes _______ and _______ bones.
Thin and fragile
Osteogenesis imperfecta causes abnormal synthesis of __________.
Type I collagen
Blue sclera and opalescent teeth (like dentinogenesis imperfecta) are associated with _____________.
Osteogenesis imperfecta
____________ is also known as the “marble bone disease”.
Osteopetrosis
Osteopetrosis results in ______ and ________ bones.
Thick and fragile
Osteopetrosis results from defective _________ function.
Osteoclast
___________ can result in osteopetrosis due to replacement of marrow stem cells.
Pancytopenia (anemia, thrombocytopenia, leukopenia)
Osteoporosis involves the increased porosity of the skeleton from _________.
Reduced bone mass
_____________ is the most common form of acquired, metabolic bone disease.
Osteoporosis
What is the most at risk group for Osteoporosis?
Post-menopausal women
Reduced estrogen
T/F: By age 90 50% of women will sustain fractures due to osteoporosis.
True
In osteoporosis, _________ activity outweighs __________ activity.
Osteoclast; osteoblast