Musculoskeletal Flashcards

1
Q

Function of the osteoblast bound RANK ligand with the osteoclasts bound RANK receptor has what affect on the osteoclasts?

A

Promotes osteoclasts function/differentiation

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2
Q

What is the function of osteoprotegerin?

A

Blocks RANK ligand/receptor binding and therefore inhibits osteoclasts function

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3
Q

T/F: IL-1 and TNF-alpha stimulate osteoclasts activity.

A

True

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4
Q

Osteogenesis Imperfecta is a hereditary disorder that causes _______ and _______ bones.

A

Thin and fragile

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5
Q

Osteogenesis imperfecta causes abnormal synthesis of __________.

A

Type I collagen

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6
Q

Blue sclera and opalescent teeth (like dentinogenesis imperfecta) are associated with _____________.

A

Osteogenesis imperfecta

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7
Q

____________ is also known as the “marble bone disease”.

A

Osteopetrosis

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8
Q

Osteopetrosis results in ______ and ________ bones.

A

Thick and fragile

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9
Q

Osteopetrosis results from defective _________ function.

A

Osteoclast

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10
Q

___________ can result in osteopetrosis due to replacement of marrow stem cells.

A

Pancytopenia (anemia, thrombocytopenia, leukopenia)

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11
Q

Osteoporosis involves the increased porosity of the skeleton from _________.

A

Reduced bone mass

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12
Q

_____________ is the most common form of acquired, metabolic bone disease.

A

Osteoporosis

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13
Q

What is the most at risk group for Osteoporosis?

A

Post-menopausal women

Reduced estrogen

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14
Q

T/F: By age 90 50% of women will sustain fractures due to osteoporosis.

A

True

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15
Q

In osteoporosis, _________ activity outweighs __________ activity.

A

Osteoclast; osteoblast

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16
Q

DEXA scans can detect _____________.

A

Osteoporosis

17
Q

Paget disease results in ________ but fragile bone that is prone to fracture.

A

Dense

18
Q

T/F: Paget disease normally affects adults and multiple bones.

A

True

19
Q

Which disease results in “Leontiasis ossea”, the face of the lion?

A

Paget disease

20
Q

T/F: Paget disease leads to an increased risk of osteosarcoma.

A

True

21
Q

End stage renal disease or vitamin D deficiency will often lead to _______________.

A

Secondary Hyperparathyroidism

Causes poor calcium retention

22
Q

T/F: PTH tells the bones to hold on to calcium.

A

False

Stimulates osteoclasts to break down bone and increase Ca serum levels

23
Q

Adenoma, carcinoma, or hyperplasia of the parathyroid gland will cause ___________.

A

Primary hyperparathyroidism

Rare but severe

24
Q

______________ result from Osteitis fibroma cystica.

A

Brown tumors

Hyperparathyroidism

25
Q

T/F: Osteomyelitis is usually caused by a virus.

A

False

Bacterial

26
Q

Osteomyelitis can cause an area of non-vital bone (___________), surrounded by vital bone (____________).

A

Sequestrum; involucrum

27
Q

In fibrous dysplasia, normal bone is replaced with fibrous ___________.

A

Connective tissue

28
Q

T/F: Fibrous dysplasia often affects one bone and young adults.

A

True

29
Q

Fibrous dysplasia of multiple bones is normally associated with _________ and endocrine disorders.

A

Cafe-au-lait spots

brownish skin spots

30
Q

____________ will cause a ground glass appearance in radiographs.

A

Fibrous dysplasia

31
Q

T/F: Osteosarcoma normally affects older adults.

A

False

Under 20 years old

32
Q

Where are the majority of osteosarcoma?

A

Knees and hips

33
Q

T/F: Osteosarcoma can have a sunburst appearance.

A

True

34
Q

___________ is an older persons disease resulting from degeneration of articular cartilage.

A

Osteoarthritis

35
Q

What is the major pathogenesis of gout?

A

Uric acid accumulation resulting in episodic acute arthritis

36
Q

Most gout cases will affect which part of the body?

A

Great toe of adult males

37
Q

_____________ is an X-linked disorder causing an absence of dystrophin.

A

Duchenne MD

38
Q

T/F: There is no treatment available for muscular dystrophy.

A

True

39
Q

Problems with eye muscles and muscles of mastication may be the initial presentation of ____________.

A

Myasthenia gravis