Vitamin C/Ascorbic Acid Flashcards
One hydrogen off of ascorbic acid is
ascorbate
Two hydrogens off of ascorbic acid is
dehydroascorbate
What are the transporters for Vit C
sodium dependent transporters 1 and 2 (SVCT1 and 2)
what destroys ascorbic acid
heat, oxidation, alkaline solutions
what are the functions of vitamin c
cofactor, antioxidant, hydroxilation, collagen synthesis, carnatine synthesis, tyrosine metabolism, neurotransmitter synthesis, proxidant, enhance immune function
what is the common interaction we see with Vitamin C
Vit C increases absorption of nonheme iron
In what way does Vitamin C influence Iron
Stabilizes from ferric (F3+) to Ferrous (F2+)
What are some excellent sources of vitamin C
red peppers, oranges, orange juice, kiwi, broccoli, strawberries, brussels sprouts
what are some good sources of vitamin c
spinach, green peas
where is Vitamin C absorpbed
in the small intestine, usually the proximal jejunum
what transporters are used to transport dehydroascorbic acid
GLUT 1 and 3
what happens to excess vitamin C
excreted in urin within 6 hrs
how to classify scurvy
total pool <300mg, plasma <0.2mg/dL
what are the four Hs of scurvy s/s
hemorrhagic, hyperkeratosis, hypochondriasis (neurological), and hematologic abnormalities
examples of deficiency s/s
fatigue, malaise, impaired wound healing, arthralgia,petechiae, corkscrew hair, swollen/bleeding gums
toxicity s/s
osmotic diarrhea, ab pain
what are some population based toxicity
renal dysfunction due to nephrolithiasis (kidney stones) and iron toxicity for individuals with disorders of iron metabolism
what is the RDA for Vit C
90mg Men, 75 mg Women
what are the recommendations for smokers
increase their vit C intake by 35 mg
what are the recommendations for pregnant women
increase vit C intake by 100mg
what is the TUL for vit C
2g both men and women
