Viral hepatitis Flashcards
Hep A - transmission
Faecal-oral
Hep A - cause
Travellers (India) Poor hygiene Overcrowding Gay men PWID
Hep A - acute or chronic?
Acute
NEVER chronic
Hep A - incidence in UK
Decreasing
Hep A - investigations
Lab conformation
- clotted blood for serology
- Hep A IgM (marker of acute current infection)
Hep B - transmission, cause
Sex
Mother to child - vertical
Blood - tattoos, blood transfusion, needlestick
Hep B - acute or chronic?
Acute and chronic
Adult infected - more likely to be acute
Child infected - more likely to be chronic
Hep B - investigations
HBsAg - antigen present on surface of hep B virus, indicates current infection (either acute or chronic)
HBeAg - present in highly infectious individuals
Anti-HBs - hep B surface antibody. Present if a person has been vaccinated against the disease or has gained natural immunity
Anti HBc - Previous or ongoing infection. Pt has had the infection at some point
IgM anti HBc - Acute infection, infection in the past 6 months
Hep B - management (chronic)
Peg interferon alone
Antiviral drugs (-ivir)
Hep C - transmission, cause
Similar to hep B Sex Mother to child Blood - tattoos, needlestick, blood transfusion IVDU
Hep C - acute or chronic?
Acute and chronic
Most people go on to be chronically infected
Hep C - investigations
Test for antibody to Hep C
- negative: not infected
- positive: infected. Must check if it is active or past infection
—- test for hep C virus RNA by PCR
Antibody + RNA present = active infection
Hep C - management
Antiviral regime
Hep D - transmission, cause
Only present if Hep B is already present
- must be infected with Hep B first
Hep E - transmission, cause
Tropics
Zoonoses
Faecal-oral transmission