Gallstones Flashcards
What are gallstones?
Hard stone like material formed within the biliary system, mainly in the GB
They make the bile sticky and thick
Why do gallstones occur?
Formed when there is an imbalance between the ratio of cholesterol to bile salts
Cholesterol stones
Excess cholesterol in bile, crystals of cholesterol
Pigment stones
Bilirubin excess
Crystals of bilirubin form
Aetiology (5 F’s)
Female Forty Fertile Fat Fair
Complications
Acute cholecystitis Chronic cholecystitis Empyema Carcinoma Ascending cholangitis Obstructive jaundice Gallstone ileus Acute pancreatitis
Biliary colic - clinical presentation
Gradual build up of RUQ pain Pain lasts for 2-6 hours Radiates to the back or right shoulder Loss of appetite - exacerbated by eating (?) Nausea Indigestion
Biliary colic - management
Pain killers
Low fat diet
Observations every 3-6 months
Symptoms gradually worsen:
Fit - cholecystectomy
Unfit - ursodeoxycholic acid
What is cholecystitis?
Inflammation of the gall bladder due to gallstones.
Gallstones obstructing the outflow of bile (cystic duct)
Acute or chronic
Acute cholecystitis - clinical presentation
Sudden sharp RUQ pain Radiates to right shoulder Persistent pain Fever Jaundice N&V Sweating Loss of appetite
Acute cholecystitis - investigations
Murphy's sign +ve (deep inspiration, sudden pain as GB hits hand) Blood tests US (first line imaging) MRCP +/- ERCP CT scan
Acute cholecystitis - management
Fasting
IV fluids
IV antibiotics
Cholecystectomy
- either within a few days of presentation
- OR elective surgery 3-6 months later
Chronic cholecystitis - what is it?
May develop after bouts of acute cholecystitis
GB wall is thickened due to fibrosis
Chronic cholecystitis - clinical presentation
Severe RUQ pain Radiates to the back or right shoulder Fever Jaundice Itch N&V Pale stools
Chronic cholecystitis - investigations
Murphy's sign +ve Blood tests US CT MRCP +/- ERCP
Chronic cholecystitis - management
Cholecystectomy
Gallstones in CBD - clinical presentation
Jaundice
Itch
Nausea
Loss of appetite
Gallstones in CBD - investigations
MRCP
Obstructive LFTs - Increased ALP, increased GGT
Gallstones in CBD - management
Small stone - ERCP
Large stone - surgery
Gallstones causing acute pancreatitis - management
Cholecystectomy
Frail - ERCP
Gallstone ileus - what is it?
Fistula between the GB and duodenum
Gallstone passes through the SI causing a blockage
Gallstone ileus - clinical presentation
Intermittent colic
Swollen abdomen
Gallstone ileus - management
Urgent/elective cholecystectomy