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SEM-IV Terapéutica Farmacológica > VIH > Flashcards

VIH Flashcards

1
Q

Farm para VIH

A

Inh de transcrip rev (NRTI)
Inh de trancrip rev NO nuc (NNRTI)
Inh de proteasa (PI)
Inh de entrada
INIs

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2
Q

NRTI

A

Zidovudina
Lamivudina
Tenofovir
Emtricitabina

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3
Q

NRTI nucleótidos

A

Tenofovir
Emtricitabina

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4
Q

NRTI nucleósidos

A

Zidovudina
Lamivudina

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5
Q

NNRTI

A

Efavirenz
Nevirapina

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6
Q

PI

A

Lopinavir
Darunavir
Ritonavir

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7
Q

INIs

A

Dolutegravir
Raltegravir
Bictegravir

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8
Q

Inh de entrada

A

Inh de fusión
Bloq de CCR5

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9
Q

Bloq de CCR5

A

Maraviroc

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10
Q

Inh de fusión

A

Enfuvirtida

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11
Q

PreP

A

Emtricitabina + Tenofovi

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12
Q

PeP

A

2 Inhibidores de la transcriptasa + 1 INIs
Tenofovir + Emtricitabina + Dolutegravir o Raltegrav

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13
Q

TARGA (HAART) esquema inicial

A

2 NRTI + 1 INIs

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14
Q

Ejemplo de TARGA

A

Tenofovir
Emtricitabina
Dolutegravi

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15
Q

Protocolo de riesgo de contaminación en MIPs

A

PEP
Idealmente primeras 2 hrs / max 72 hrs
28 días

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16
Q

Esquema preferido en MIPs

A

Tenofovir
Emtricitabina
Dolutegravi

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17
Q

NRTI barrera genética alta

A

Dolutegravir
Darunavir

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18
Q

Características de NRTI barrera genética alta

A

Se requieren mult mut para resistencia

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19
Q

NRTI barrera genética media

A

Tenofovir
Abacavir

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20
Q

Características de NRTI barrera genética media

A

Se requieren pocas mut para resistencia

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21
Q

NRTI barrera genética baja

A

Lamivudina
Efavirenz

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22
Q

Características de NRTI barrera genética baja

A

Se requiere una sola mut para resistencia

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23
Q

MoA de NRTI competitivos

A

Se incorporan a DNA viral e inh transcriptasa rev

24
Q

MoA de NRTI NO competitivos

A

Inh transc rev en sitio NO competitivo

25
Indicas de NRTI competitivos
1º VIH Hijos y madres Hep B
26
NRTI para hep B
Lamivudina Emtricitabina Tenofovir
27
EA de NRTI competitivos
Lipodistrofia Esteatosis hep Pancreatitis Tox mitocondrial
28
Tox mitocondrial
Neuropatía Miopatía Acidosis láctica
29
EA de abacavir
Hipersens HLA-B
30
EA de tenofovir
Nefrotox Osteoporosis
31
NNRTI con vida media + larga
Efavirenz
32
Indicas de nevirapina
Prevención de transm vertical en embarazo
33
NRTI competitivos
Zidovudina Lamivudina Tenofovi
34
NRTI NO competitivos
Nevirapina Efavirenz
35
Indicas de NRTI NO competitivos
Alternativa
36
EA de nevirapina
Rash Hepatotox Necrosis epi Steven Johnson
37
EA de efavirenz
Sueños viv Psiquiátricos Teratogénico
38
MoA de PI
Inh proteasa lo que impide maduración de viriones
39
Indicas de PI
Combinado con ritonavir / cobisistat para pot efe
40
Potencia de PI
Alta
41
Barrera genética de PI
Buena
42
EA de PI
Metabólicos - Hiperlipidemia - Resist a insulina GI - Nausea - Diarrea
43
MoA de INI
Inh integrasa lo que evita unión con DNA humano
44
Indicas de INIs
1º VIH
45
Potencia de INIs
Muy alta
46
Tolerancia de INIs
Excelente
47
Resistencia a INIs
Baja
48
EA de INIs
Erupciones cut Mialgias Aumento CPK
49
MoA de enfuvirtida
Bloq de gp41 e impide fusión con la c.
50
MoA de maraviroc
Antag de coR CCR5
51
Indicas de enfuvirtida
Cepas que desarrollan resistencia a otros
52
EA de enfuvirtida
Dolor Nódulos en sitio de iny.
53
Indicas de maraviroc
Terapia antiretrovir altamente activa (HAART)
54
Contraindicas de maraviroc
Cepas de VIH que se unen a R CXCR4
55
¿Qué prueba requiere maraviroc?
Prueba de tropismo

SEM-IV Terapéutica Farmacológica (37 decks)

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