Ventricular system & Blood brain barrier Flashcards

1
Q

What are the four cavities filled with Cerebrospinal fluid in the brain?

A
  • Two lateral ventricles
  • Third ventricle
  • Fourth ventricle
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2
Q

Fill in the blanks .” The lateral ventricles communicate with the third ventricle via _________.”

A

Interventricular foramen of Munro

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3
Q

Fill in the blanks . “ The their ventricle is connected with the fourth ventricles via _________.”

A

Cerebral aqueduct of Sylvius

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4
Q

What is the embryological origin of the ventricles of the brain?

A

The cavity of the neural tube

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5
Q

What lines the Ventricles?

A

Ependyma

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6
Q

True or False? The Fourth ventricle continuous with central canal in spinal cord and the Central canal dilated at its inferior end - terminal ventricle.

A

TRUE!!

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7
Q

What are the functions of the Ependymal cells?

A
  1. They line the ventricular cavities and the central canal.
  2. They provide nutrition for the stem cells in the sub-ventricular system.
  3. They have a role in immune defence
    - they produce cytokines, toll- like receptors etc.
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8
Q

Where is the body of the Lateral ventricle located?

A

In the Parietal lobe

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9
Q

Where is the anterior horn of the lateral Ventricle located?

A

In the frontal lobe

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10
Q

Where is the posterior horn of the lateral ventricle located?

A

In the occipital lobe

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11
Q

Where is the Inferior horn of the lateral ventricle located ?

A

In the Temporal lobe

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12
Q

What are the parts of the Body of the lateral ventricle?

A

Roof
Floor
Median wall

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13
Q

What form the Roof of the body of the lateral ventricle ?

A

The roof is formed by the undersurface of Corpus callosum

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14
Q

What structure forms the Floor of the body of the lateral ventricle?

A

The floor is formed from the Body of Caudate Nucleus and Margin of Thalamus .

  • Superior surface obscured by Body of fornix
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15
Q

What structure forms the median wall of the body of the lateral ventricle ?

A

Formed by septum pellucidum anteriorly and posteriorly, roof and floor come together

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16
Q

What forms the Roof of the Anterior horn of the lateral ventricle?

A

Formed by undersurface of anterior part of corpus callosum

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17
Q

What structure limits the anterior horn anteriorly ?

A

The Genu of Corpus callosum

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18
Q

What forms the Floor of the Anterior horn of the Lateral ventricle ?

A

The head of the Caudate nucleus

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19
Q

What structure forms the Median wall of the Anterior horn pf the lateral ventricle?

A

Formed by septum pellucidum and anterior column of fornix

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20
Q

What forms the Roof and Lateral wall of the Posterior horn of lateral ventricle?

A

Formed by fibers of tapetum of corpus callosum.

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21
Q

What structure is located lateral to the Tapetum?

A

The fibres of Optic radiations

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22
Q

What forms the Medial wall of the Posterior horn of the lateral ventricle?

A

Superior swelling caused by forceps major of corpus callosum: bulb of posterior horn

Inferior swelling produced by calcarine sulcus- Called calcar avis

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23
Q

What is the bulb of the Posterior horn?

A

Superior swelling caused by forceps major of corpus callosum

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24
Q

What is the Calcar Avis?

A

Inferior swelling produced by the Calcarine sulcus.

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25
Q

What structure forms there roof of the inferior horn of the lateral ventricle ?

A

Formed by inferior surface of tapetum of corpus callosum and by tail of caudate nucleus

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26
Q

What structure is located in between Stria terminals and the tail of the Caudate nucleus?

A

Thalamo-striate vein or vena terminalis

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27
Q

What structures forms the Floor of the inferior horn of the lateral ventricle ?

A

Formed laterally by collateral eminence, produced by collateral fissure and medially by hippocampus

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28
Q

What epithelium is the Choroid plexus of the lateral ventricle?

A

Cuboidal epithelium

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29
Q

What is the structure of the Choroid plexus composed of?

A

Made of Pia mater with ependymal lining of Ventricular cavity

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30
Q

True or False?At junction of body of lateral ventricle and inferior horn, choroid plexus
continues into inferior horn and projects through choroidal fissure.

A

TRUE!!

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31
Q

What forms the Anterior Wall of the third ventricle?

A

Lamina terminalis

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32
Q

What forms the Posterior wall of the third ventricle?

A

The opening from into Cerebral aqueduct

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33
Q

What structure is found superior to the opening of the Cerebral acquedtuct?

A

The Posterior commissure

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34
Q

What structure is found superior to the pineal recess?

A

The Habenular commissure

35
Q

What is the name of the structure that connects the right and left temporal lobes?

A

The anterior commissure

36
Q

What is the name of the structure that forms the Lateral wall of the Third ventricle?

A

It is formed by medial surface of Thalamus ( superiorly) and Hypothalamus (inferiorly)

37
Q

What is the name of the structure that limits the lateral wall of the third ventral?

A

Stria Medullaris Thalami

38
Q

Fill in the blanks. “ The lateral walls of the third ventricle are joined by_________.”

A

Interthalamic Adhesion

39
Q

What is the food of the third ventricle formed by?

A

Layer of ependyma continuous with lining of ventricle

40
Q

What forms the Floor of the Third ventricle ?

A

M - Mamillary bodies
I - Infundibulum
T- Tuber cinerum
O - Optic chiasma

41
Q

What is the name given to the two-layer fold of Pia mater found in the third ventricle?

A

Tela Chrodiae

42
Q

How long is the Cerebral aqueduct of Sylvius?

A

1.8 cm

43
Q

What is the name given to the layer of Grey matter that surrounds the Cerebral aqueduct?

A

Central Grey

44
Q

True or False? There is NO choroid plexus found in the cerebral aqueduct.

A

TRUE!!

45
Q

What is the blood supply to the Fourth ventricle?

A

Posterior inferior cerebellar arteries

46
Q

Fill in the blanks. “ For the lateral boundaries of the Fourth Ventricle , the Cranial part of each lateral boundary formed by ______________ and the Caudal part of each lateral boundary formed by ______________.”

A

Cranial- Superior Cerebellar Peduncle

Caudal - Inferior Cerebelllar Peduncle

47
Q

True or False? The fourth ventricle communicates with subarachnoid space through single median opening and two lateral apertures.

A

TRUE!!

48
Q

Fill in the blanks. “ The roof of the Fourth has a Superior part formed by medial borders of two ______________ and connecting sheet of white matter called: _____________.”

A

Two superior cerebellar peduncles

Connecting white matter sheet called Superior Medullary Velum

49
Q

What is the name of the structure that forms the Inferior part of the Roof of the Fourth ventricle?

A

Inferior medullary velum

50
Q

What forms the Inferior medullary Velum?

A

Ventricular ependyma and posterior covering of white matter

51
Q

What is the name given to the structure that pierces part of the roof of the fourth ventricle in the midline?

A

Median aperture of Foramen of Magendie

52
Q

What structure is found lateral to the Sulcus limitans ?

A

Vestibular area

53
Q

What are the structures located in the Floor of Fourth ventricle ?

A

From Medial to lateral:

Halle- Hypoglossal triangle with Hypoglossal nucleus .

Vacationed - Vagal triangle( position
for dorsal motor nucleus of vagus)

At - Area Postrema -

Ontario - Obex- midline structure below area postrema,

54
Q

Where is the Area Postrema located in the fourth ventricle ?

A

It is located between vagal triangle and lateral margin of ventricle (dorsal part: no BBB).

55
Q

Where does the decussation of sensory fibres of the medial leminiscus occur along with the entrance of the central canal?

A

The Obex

56
Q

Fill in the blanks. “ In Conus medullaris of the spinal cord , the central canal extends to form _______.”

A

The terminal ventricle

57
Q

True or False? There is NO Choroid plexus in the central canal.

A

TRUE !!!

58
Q

What is the name of the gray matter that surround the Central canal?

A

Grey Commisure

59
Q

Fill in the blanks.” The Cerebellomedullary cistern receives CSF from the fourth ventricle through __________.”

A

The foramen of Magendie

60
Q

What structures are found in the Cerebellomedullary cistern?

A
  • The Vertebral artery
  • The origin of the Posterior Inferior Cerebellar Artery (PICA)
  • CN 9,10,11 & 12
  • Choroid plexus
61
Q

True or False? The Lumbar cistern receives CSF through the Foramen of Luschka.

A

FALSE!! The Pontine Cistern receives CSF via the Foramen of Luschka

62
Q

Which arteries are found in the Pontine Cistern?

A
  • Basilar Artery
  • Origin of Anterior
  • Inferior Cerebellar artery ( AICA)
    CN 6
63
Q

Where is the Interpeduncular cistern located?

A

Between the two Cerebral peduncles and the Dorsum Sellae

64
Q

What structures are found in the Interpeduncular Cistern ?

A

Optic Chiasma
CN 3 ( Occulomotor nerve )
Numerous vessels

65
Q

Where does Conus Medullaris lie?

A

L1-2

66
Q

Where is the Lumbar Cistern located?

A

From conus medullaris (L1-2) to S2. Contains filum terminale and roots of cauda equina. CSF is withdrawn from this cistern during lumbar puncture.

67
Q

What separates the blood of capillaries from the ventricular lumen?

A

Endothelium ,Basement membrane & surface epithelium

68
Q

What is the main site of Absorption of CSF?

A

Arachnoid villi projecting into dural venous sinuses (superior sagittal sinus).

69
Q

True or False? The arachnoid villi decreases in number and size as one ages.

A

FALSE!! It increases in number and size with age and tend to become calcified

70
Q

What are the three origins associated with increased pressure of CSF for Hydrocephalus?

A

+ Abnormal increase in formation of CSF.

+ Blockage of circulation of CSF.

+ Reduced absorption of CSF.

71
Q

An obstruction in the foramen of Magendie will cause what condition?

A

Chiari malformation

M for Magendie M for Malformation

72
Q

An obstruction in the Foramina of Luschka will cause what condition?

A

Dandy- Walker Syndrome

73
Q

What molecules DO NOT pass the Blood Brain Barrier?

A

Molecules with molecular weights of 60,000 and above do not cross the BBB

74
Q

What are the Areas with No Blood Brain Barrier?

A

L - Lamina Terminalis
A- Area Postrema
P- Posterior Pituitary ( Neurohypophysis)
D- Dorsal root ganglion
Shot - Sunfornical organs
Two - Tuber-cinerum
Medical - Median Emminence
Practicioners- Pineal Gland
Today - Trigeminal ganglion

” LAPD Shot Two Medical Practitioners Today”

75
Q

What are the three structures that make up the Blood Brain barrier?

A
  1. Endothelial cells found inside the wall of capillary
  2. Basement membrane found outside the endothelial cells
  3. The foot processes of the Astrocytes adhering to the outer surface of the capillary
76
Q

What type of collagen is found in the Basal lamina?

A

Type IV

77
Q

What are the components of the Basal Lamina?

A

Type IV collagen
Heparin sulfate
Fibronectin
Laminin

78
Q

What structure works with Intergrins to regulate permeability of the BBB and cellular transport across it ?

A

Laminin

79
Q

What is the name given to contractile cells that wrap around the endothelial cells of capillaries and venules throughout the body?

A

Pericytes

80
Q

Which cells contribute to the formation of Tight junctions?

A

Pericytes

81
Q

True or False? Pericytes Increases with age .

A

FALSE!!Pericytes decrease with age, paralleling an increase in BBB permeability.

82
Q

What are the different functions of Pericytes?

A
  1. . They are macrophage-like cells with smooth muscle properties and are embedded in the basement membrane around the blood vessels
  2. Pericytes contribute to the formation of tight junctions.

3.They regulate permeability of the BBB by release of vasoactive substances.

83
Q

What are the three proteins that forms the tight junctions in the Blood Brain Barrier?

A

Occludin
Claudin
Junction adhesion molecules (JAMs)

84
Q
A