Vaccines 3 Flashcards

1
Q

Why is adjuvant added to antigen?

A

The compound is added to the antigen to make it more immunogenic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What does the adjuvant create?

A

Creates a depot effect (retains antigen at site)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What does the adjuvant promote?

A

Promotes uptake of the antigen (phagocytosis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What does the adjuvant activate?

A

Activates innate immunity (co-stimulation)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the oldest component of the vaccine?

A

Adjuvant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What 5 things does the adjuvant compound usually consist of?

A
  1. Oils
  2. Metal salts (alum)
  3. Microbial cell wall components
  4. Nucleic acids
  5. Preservative (mercury)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What does alum do?

A

REALLY irritating
Phagosome tries to eat it, but it can’t
Increases innate immune cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What type of specificity do adjuvants have?

A

Target independent (for any vaccine)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What 3 things does the route and does control?

A
  1. How the immune system “sees”
  2. Magnitude of response
  3. Generation of immunological memory
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Systemic immunity
How is it delivered?
How does it work?

A

Subcutaneous and intramuscular

Slow absorption, transport to local lymph nodes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Mucosal immunity
How is it delivered?
How does it work?

A

Intranasal or oral

Rapid absorption, involvement of mucosal lymphoid tissues

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

How can we indue a strong T-cell memory

A

Using appropriate prime-boost strategies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Oils/Emulsions

A

Depot effect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Alum

A

Ag retention, Phagocyte activation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Microbial products

A

Activate Leukocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Nucleic Acids

A

Activate Leukocytes

17
Q

Free antigen is taken up by

A

Macrophages
DC
B-cells

18
Q

MHC 1

A

present antigens to cytotoxic T-cells w/ CD8+ receptors (killer)

19
Q

MHC 2

A

present antigens to helper t-cells w/ CD4+ receptors

20
Q

What is antigen presented on the surface of?

21
Q

What two things do the CD8+ T-cells do?

A
  1. Proliferate and egress out of LN to clear pathogen

2. Some differentiate into memory cells

22
Q

What three things do the CD4+ cells do?

A
  1. Provide cytokines to support CD8+ expansion
  2. ” “ B-cell expansion
  3. Differentiate into memory cells
23
Q

List 2/5 things happening in the germinal center

A
  1. Massive B-cell Proliferation

2. Mutation of the Antibody genes

24
Q

List the other 3 things happening in the germinal center

A
  1. Selection of cells producing high affinity antibodies
  2. Isotype class switching
  3. IgM producing cells switch to produce IgG, IgA
25
What is another name for herd immunity?
Halo effect
26
How can vaccines protect those that have not been vaccinated?
If the % of the pop. vaccinated is high enough, is reduces the likelihood that an unimmunized person will come into contact with an infected person
27
How can we create the odds of bumping into an infected person low?
Herd immunity | Halo effect
28
What % do we need to vaccinate to achieve herd immunity?
It depends on the transmissibility of the pathogen
29
Is a vaccine 100% safe?
No
30
What are some adverse reactions of a vaccine?
Inflammation at the site, mild disease like symptoms, fever, irritability, lethargy
31
What are potentially life-threatening reactions for vaccines?
Anaphylactic shock