Innate Immune Mechanisms

Question 1

What are the 5 innate immune mechanisms?

Answer 1

1. Inflammation
2. Cellular recruitment
3. Phagocytosis
4. Ox Burst
5. NETs

Question 2

What is the earliest recognition of immune response?

Answer 2

Inflammation

Question 3

Inflammation is an innate, non-specific, broad immune response that involves what 4 things?

Answer 3

1. Vascular permeability
2. Cellular recruitment
3. Cellular proliferation
4. Metabolism

Question 4

What is inflammation mediated by?

Answer 4

Production of cytokines, chemokines and other soluble mediators

Question 5

Inflammation is the increase in vascular dilation which allows increased blood flow. What does this lead to?

Answer 5

Increased cells and plasma proteins entering tissue, increased lymph drainage and increased trafficking of DC to LN

Question 6

What are cytokines?

Answer 6

Small proteins that respond to a stimulus and induce a response in a target cell by binding to a receptor

Question 7

What are the 4 major families of cytokines?

Answer 7

Interleukins
Hematopoietins
Tumor-necrosis factor
Interferons

Question 8

What are chemokines?

Answer 8

Chemoattractant cytokines - cytokines that induce cellular adhesion in response to a gradient