Innate Immune Cells

Question 1

Where do pluripotent hematopoietic stem cells live?

Answer 1

Bone marrow

Question 2

DO pluripotent Hematopoietic Stem Cells directly differentiate into immune cells?

Answer 2

No

They pass thru stages of differentiation

Question 3

What are the intermediate stages of differentiation referred to as?

Answer 3

Common progenitor cells

Question 4

What are the 6 innate immune cells?

Answer 4

1. Macrophage
2. Dendritic cell
3. Neutrophil
4. Eosinophil
5. Basophil
6. Mast cell

Question 5

Monocytes are a “-“ macro

Answer 5

Blood

Question 6

Macrophages are a “-“ monocyte

Answer 6

Tissue

Question 7

Macrophages reside in every…

Answer 7

Tissue

Question 8

What are the three antigen-presenting cells (APC) of the innate?

Answer 8

1. Macro
2. Den
3. B cell

Question 9

What are the 2 activated functions of a macrophage?

Answer 9

1. Phagocytosis and activation of bactericidal mech

2. Antigen-presenting

Question 10

What type of nucleus does a macrophage have?

Answer 10

Round

Question 11

Dendritic cells are similar to a —— but aren’t great at ——–

Answer 11

Macrophage

killing

Question 12

Why would dendritic cells leave the site where the pathogen is?

Answer 12

To educate the lymph nodes and display for T-cells to see

Question 13

What is the single most important cell type for the activation of naive T-cells?

Answer 13

Dendritic cells

Question 14

What is distinct about Neutrophils structure?

Answer 14

3 lobe nucleus

Question 15

What is the workhorse of the innate?

Answer 15

Neutrophils

Question 16

What innate immune cells lives for 1-2 days?

Answer 16

Neutrophils

Question 17

Where do neutrophils live?

Answer 17

Blood and have to be recruited to an infected tissue

Question 18

Are neutrophils granulocytes?

Answer 18

YES

Question 19

What is the single best phagocyte?

Answer 19

Neut

Question 20

What are the 5 effector mech of neutrophils?

Answer 20

1. Phago
2. Degranulations
3. Ox burst
4. Cytokines
5. NETs

Question 21

What are the 3 types of granules in neutrophils?

Answer 21

1. Azurophilic
2. Specific
3. Gelatinase

Question 22

Azurophilic

Answer 22

Primary granule

Reactive ox

Question 23

what is the activated function of an eosinophil?

Answer 23

Kill parasites - relase toxic bombs

Question 24

What is the activated function of a basophil?

Answer 24

Deals w/ parasites

Question 25

Mast cells

Answer 25

Allergy

Release of granules containing histamine and active agents