Innate Immune Cells Flashcards
Where do pluripotent hematopoietic stem cells live?
Bone marrow
DO pluripotent Hematopoietic Stem Cells directly differentiate into immune cells?
No
They pass thru stages of differentiation
What are the intermediate stages of differentiation referred to as?
Common progenitor cells
What are the 6 innate immune cells?
- Macrophage
- Dendritic cell
- Neutrophil
- Eosinophil
- Basophil
- Mast cell
Monocytes are a “-“ macro
Blood
Macrophages are a “-“ monocyte
Tissue
Macrophages reside in every…
Tissue
What are the three antigen-presenting cells (APC) of the innate?
- Macro
- Den
- B cell
What are the 2 activated functions of a macrophage?
- Phagocytosis and activation of bactericidal mech
2. Antigen-presenting
What type of nucleus does a macrophage have?
Round
Dendritic cells are similar to a —— but aren’t great at ——–
Macrophage
killing
Why would dendritic cells leave the site where the pathogen is?
To educate the lymph nodes and display for T-cells to see
What is the single most important cell type for the activation of naive T-cells?
Dendritic cells
What is distinct about Neutrophils structure?
3 lobe nucleus
What is the workhorse of the innate?
Neutrophils
What innate immune cells lives for 1-2 days?
Neutrophils
Where do neutrophils live?
Blood and have to be recruited to an infected tissue
Are neutrophils granulocytes?
YES
What is the single best phagocyte?
Neut
What are the 5 effector mech of neutrophils?
- Phago
- Degranulations
- Ox burst
- Cytokines
- NETs
What are the 3 types of granules in neutrophils?
- Azurophilic
- Specific
- Gelatinase
Azurophilic
Primary granule
Reactive ox
what is the activated function of an eosinophil?
Kill parasites - relase toxic bombs
What is the activated function of a basophil?
Deals w/ parasites
Mast cells
Allergy
Release of granules containing histamine and active agents
