Antibody Structure and Function 2 Flashcards
1
Q
What are the two potential mechanisms for allergy treatment?
A
- Immune tolerance
2. Make IgG instead of IgE
2
Q
Surface Ig (sIg) has short cytoplasmic domians. What does this mean it has trouble doing?
A
It is unable to mediate intracellular signals
3
Q
SiG associates with the Ig superfamily members ?(2)
A
Igalpha and Igbeta
4
Q
What is ITAM?
A
helps Iga and Igb to generate intracellular signals
5
Q
Ig bound to Ag can activate what classical system?
A
Complement!
6
Q
What is required to start the complement process?
A
C1q to bind to at least two Fc regions
7
Q
How many Fc regions does IgM have?
A
5 - it is pentameric
8
Q
What does the binding of C1q induce?
A
A conformational change of activating a serine protease
9
Q
What must an a Bcell encounter to survive?
A
Antigen
