V1: Hepatitis Viruses Flashcards
What are the main targets of the true hepatitis viruses?
The main targets of the true hepatitis viruses are the hepatocytes
In acute infectious fevers what do the hepatitis viruses infect?
Infect the Kuppfer cells of the reticuloendothelial system, so avoiding liver damage
What causes Hep A?
How is it spread?
- Enterovirus family
- Fecal oral contamination
- Oral anal sexual activity contamination
What are some complications of Hep A? (3)
- Fulminant hepatitis
- Cholestatic hepatitis
- Relapsing hepatitis
Where does Hep A virus replicate?
Virus replicates primarily in the hepatocytes
What is the incubation period for Hep B?
48-180 Days
What is the most likely transmission of Hep B
Through blood
What is the most affected age group?
Young adults between 20 – 39
What are some potential complications of Hep B? (3)
- Chronic hepatitis
- Cirrhosis
- Liver cancer
What are the 3 important antigens in Hep B?
- HBcAg
- HBeAg
- HBsAg
Presence of HBeAg indicates what?
That the blood contains Dane particles and is infective for others
What do the following antibodies indicate?
- Anti-HBs
- Anti-HBe
- Anti-HBc
- Anti-HBs indicates recovery, present in convalescence
- Anti-HBe indicates little or no infectivity
- Anti-HBc indicates recent infection if present in IgM form
How can you prevent transmission in a clinical setting? (3)
- Breakdown in sterilisation
- Breakdown in infection control
- Care with bodily fluids and PPE
Name 3 drugs tat can help treat Hep B
CHECK VIDEO
What does Hep D require to replicate?
Hep B
