Uses Of Complexes Flashcards
Structure of cis platin
Pt square planar (coord number of 4)
4 ligands = Cl and Cl at 90° apart as well as NH3 and NH3 at 90° apart
Why is cisplatin used in cancer treatments?
Because it prevents replication of DNA in uncontrolled cell division (so prevents growth of tumour)
Why is cisplatin used and not a mixture in its trans form to treat cancer?
Because cisplatins structure allows it to form links to DNA molecule since the Cl atoms are close to prevent dna replication
But transplatin is not effective in this
Tollens reagent structure
1 Ag+ ion datively bonded to 2 NH3
Overall charge of +1
180° bond angle
Linear shape
Haemoglobin structure
Contains 4 iron complexes per haemoglobin:
Iron 2+ ion forms dative bonds to 4 nitrogen in 4 haem units which connect each other by a porphyrin ring
And connected to the globin protein by nitrogen
Leaves 1 dative bond to oxygen. Co ord number of 6 = octahedral
Haem units are a…
Tetradentate ligand because 4 pairs of electrons are datively bonded to the iron ion and connected to each other by a porphyrin ring
Haem unit
Tetradentate ligand connected by a porphyrin ring to the iron 2 ion
Why is CO better at binding to haemoglobin than oxygen?
Because CO is a better ligand than O2
So Co replaced water ligand to iron 2 to form a very stable complex that oxygen cannot disrupt
Ligand exchange in haemoglobin
Oxygen molecule ligand to iron 2 is substituted for CO ligand
