Unit 4 Flashcards
what type of CA occurs in the liver
primary
secondary
which type of liver cancer is more common and why
secondary dt livers inc size, perf, portal drainage
2 types of primary liver ca
hepatocellular carcinoma
cholangiocarcinoma
how much of primary liver ca does hepatocellular carcinoma make up
90%
where does hepatocellular carcinoma originate
hepatocytes
2 main ets of hepatocellular carcinoma
chronic liver disease
environmental toxins
why may chronic liver disease predispose you to hepatocellular carcinoma
viruses in host cell may alter cell dna -> ca
mnfts of hepatocellular carcinoma
insidious onset
similar mnfts to preceeding liver disease
mnfts are often masked if CLD is present
what is the prognosis for hepatocelluar carcinoma
poor, cancer is usually well progressed when dx
if hepatocellular carcinoma is detected early, what is the tx
partial hepatectomy
tx for late dx hepatocellular carcinoma
palliatve care, chemo, radiation
what is another class of hepatocellular carcinoma
hepatic adenoma
which population has inc risk for hepatic adenoma
inc in 20-30 yo females on BCP
where does hepatic adenoma arise from
own hepatocytes and blood supply
risk of hepatic adenoma
can ruputre -> hemmor
tx for hepatic adenoma
stop BCP and dec H that promotes growth
whats the prognosis for hepatic adenoma
good
where does cholangiocarcinoma originate
bile duct and epithelial tissue
who has inc predispostion for cholangiocarcinoma
pts with chronic duct inflm
where are secondary tumors from
identified primary malignancy in colon, lung, breast
mnfts of secondary tumors in liver
non spec, those of CLD (jaundice, unexplained wt loss, anorexia, fever, hepatomegaly)
whats important about the non spec mnfts of secondary tumors in liver
fever in absense of infc
unexplained weight loss
whats the prognosis for 2nd growth in liver
poor, 3-6 months to live
tx for secondary tumor growth in liver
palliative care, sx, support
who has inc risk for pancreatic ca
men, smoker, black people
what is the mortality rate for pancreatic ca
90% in first year
what type of cancer makes up 90% of pancreatic ca cases
adenoma (duct glandular epithelium
What is the leading cause of Ca death
pancreatic cancer
et of pancreatic cancer
unclear
what is pancreatic cancer linked to
smoking
alcohol
age
poor diet
what are predispostions to pancreatic cancer
DM chronic pancreatitis (not acute)
why is age linked to pancreatic ca
rt cumulative exposure to environmental triggers -> damage and genetic mutation
mfnts of pancreatic ca
dt mass taking up space in pancreas, causing inc P on ducts
jaundice, unexplained wt loss,
what is a classic mnft of pancreatic ca
abdm pain
dx pancreatic ca
US, CT
what is said about the pancreatic tumor after dx
it has normally already metastisized
tx for pancreatic ca
pain control
sx if early
palliative care
no chemo
