Unit 3 Part 3 Flashcards
acute pancreatitis
inflm of pancreas
what happens in acute pancreatitis
autodigestion
what is autodigestion
not IR related
sec of enzymes by pancreas that attack it
what tissue produces most of the ezs in in pancreatic auto digestion
exocrine
what is said about the prognosis of pancreatitis
self limiting but life threatening
Et of pancreatitis (6)
alcohol abuse (70%) gallstones hyperlipidemia idipathic inflm other : eg pancreatic trauma, drugs
why does alcohol cause pancreatitis
alcohol stimulates pancreatic juice sec -> excessive sec -> bile enters other ducts -> ez are activated outside duodenum prematurel -> ez attack pancreas
why do gallstones cause pancreatitis
block ducts -> inc sec moving down ducts -> ez activiated -> ez attack pancras
why does hyperlipidemia lt pancreatitis
extra fat -> extra bile -> stones -> duct blockage
why are ez actiavted prematurely in pancreas
inc bile sec while there is a block results in bile flowing through other ducts until it reaches the pancreas, activating ez prematurely
how do ez cause pancreatic damage
auto digestion
hemmor
necrosis
when does the hepatopancreatic sphincter open
when bile and pancreatic juice are released
what does alcohol do to the hepatopancreatic sphincter
constricts it
what happens when the hepatopancreatic sphincter is constricted
mixing of ducts
what is important to remember about the pancreas’ sensitivity and fx reserve
highly sensitive
dec fx reserve
when does pancreatitis onset
following heavy meal/alcohol binge (with hx of alcoholism) dt inc stomach content -> inc sec
what type of pain is felt in pancreatitis
sev abdm pain
epigastric pain that radiates to back
why does 3rd spacing occur in pancreatitis
rt vital organ + extensive inflm, triggering inflm response -> vasodilation and fluid shift out of pancreas into 3rd space
why does vascular collapse of the pancreas occur
dt l/o patency rt dec volume in vasculature
is there risk for hypovolima in pancreatitis
yes
what ez are elevated in blood during pancreatitis
amylase
lipase
which ez is pancreatitc specific
lipase
tx of pancreatitis (7)
pain mgmt NPO ICU sx tx complications vol expansion and paracenthesis no alcohol
how do we manage pain in pancreatitis
IV opioids
