Unit 3 Part 3

Question 1

acute pancreatitis

Answer 1

inflm of pancreas

Question 2

what happens in acute pancreatitis

Answer 2

autodigestion

Question 3

what is autodigestion

Answer 3

not IR related

sec of enzymes by pancreas that attack it

Question 4

what tissue produces most of the ezs in in pancreatic auto digestion

Answer 4

exocrine

Question 5

what is said about the prognosis of pancreatitis

Answer 5

self limiting but life threatening

Question 6

Et of pancreatitis (6)

Answer 6

alcohol abuse (70%)
gallstones
hyperlipidemia
idipathic
inflm
other : eg pancreatic trauma, drugs

Question 7

why does alcohol cause pancreatitis

Answer 7

alcohol stimulates pancreatic juice sec -> excessive sec -> bile enters other ducts -> ez are activated outside duodenum prematurel -> ez attack pancreas

Question 8

why do gallstones cause pancreatitis

Answer 8

block ducts -> inc sec moving down ducts -> ez activiated -> ez attack pancras

Question 9

why does hyperlipidemia lt pancreatitis

Answer 9

extra fat -> extra bile -> stones -> duct blockage

Question 10

why are ez actiavted prematurely in pancreas

Answer 10

inc bile sec while there is a block results in bile flowing through other ducts until it reaches the pancreas, activating ez prematurely

Question 11

how do ez cause pancreatic damage

Answer 11

auto digestion
hemmor
necrosis

Question 12

when does the hepatopancreatic sphincter open

Answer 12

when bile and pancreatic juice are released

Question 13

what does alcohol do to the hepatopancreatic sphincter

Answer 13

constricts it

Question 14

what happens when the hepatopancreatic sphincter is constricted

Answer 14

mixing of ducts

Question 15

what is important to remember about the pancreas’ sensitivity and fx reserve

Answer 15

highly sensitive

dec fx reserve

Question 16

when does pancreatitis onset

Answer 16

following heavy meal/alcohol binge (with hx of alcoholism) dt inc stomach content -> inc sec

Question 17

what type of pain is felt in pancreatitis

Answer 17

sev abdm pain

epigastric pain that radiates to back

Question 18

why does 3rd spacing occur in pancreatitis

Answer 18

rt vital organ + extensive inflm, triggering inflm response -> vasodilation and fluid shift out of pancreas into 3rd space

Question 19

why does vascular collapse of the pancreas occur

Answer 19

dt l/o patency rt dec volume in vasculature

Question 20

is there risk for hypovolima in pancreatitis

Answer 20

yes

Question 21

what ez are elevated in blood during pancreatitis

Answer 21

amylase

lipase

Question 22

which ez is pancreatitc specific

Answer 22

lipase

Question 23

tx of pancreatitis (7)

Answer 23

pain mgmt
NPO
ICU
sx
tx complications
vol expansion and paracenthesis
no alcohol

Question 24

how do we manage pain in pancreatitis

Answer 24

IV opioids

Question 25

why is the pancreatic pt NPO

Answer 25

to stop sec of juice /ez by pan

Question 26

why are DM patients especially NPO

Answer 26

correct metb abn which could result in DM dt inability to rls I when pt ingests food

Question 27

when is the pancreatitis pt in the ICU

Answer 27

severe cases resulting in renal, CV, and hepatobiliary problems

Question 28

sx as atx

Answer 28

to remove stones