Self Study 6 Flashcards
what does allgx and H dermatoses involve
inflm respoonse to multi exogenous/endogenous agents
what is allgx and H deramtoses charcterized by
epidermal edieam with seperation of epidermal cells
what dermatitis’ does allgx and H deramtoses involve
irritant contact dermatitis, allgx contact dermatits, atopic and nummular eczema, drug induced skin interuptions
contact dematitis
common inflm of skin
2 types of contact dermatitis
allergic and irritant CD
what does allgx CD result from
cell mediated, type4 H rxn
what type of reaction occurs in ACD
t cell only. no abs.
2 kinds of ACD reaction
direct cytotoxic T cell destr of macrophage
deylaed t cell prod of lymphokines that destroy ag bearing cell days later
primary lesions ACD
mild erythema with edema to vesicles or lrage bullae
secondary lesions ACD
dt bacterial infc
where do lesions in ACD occur
anywhere
ICD cause
caused by chemicals that irritate skin, environmental triggers
risk for ICD
hx of atopic dermatitis
4 types of ICD
subjective, acute, chonic, chemical burns
subjective ICD
no clinical mnfts
burning or stinging when exposed to irritant
acute ICD
due to single exposures to irritant
dryness, erythema, edmea, inflm, vesicles
chronic ICD
results from contd exposure to irritant , even when irritant removed.
dryness, erythema, sclaes, fissures, vesicles
chemical burn ICD
deep necrosis from contact with cement prod
Tx ICD
remove source
change lifestyle
minor: wash area, apply anti itch cream, topical corticosteroids?
mod - extreme: tx with wet dressing, oral antihistamine, systemic corticosteroids
eczema
inflm of skin
2 types of eczema
atopic dermatits
nummular eczema
atopic derm
ithcy, inflm skin disorder
what is atopic derm characterized by
poorly defind erythema with edema, vesicles, weeping (acute) skin thickening (chronic)
how is atopic derm often described
IgE mediated H. Similar to Allgx patho.
how do mnfts present in atopic derm
differently depending on age and race
when do 70% of atopic derm cases start
peds
what is atopic derm characterized with (mnfts)
vesicles formation, oozing, cursting
where does atopic derm begin (peds)
cheeks, progress to scalp, arms, trunk, legs
atopic derm mnfts adolsecent (acute)
dry, red patches on face, neck, upper trunk-no thickening
atopic derm mfnts adolescent (chronic)
dry, leathery, lichenfied spin
is there a gen predisopostion in atopic derm
yes
tx for atopic derm
avoid temp changes/stress skin care avoid triggers dec contact with awater meds wet derssing probiotics
why should a person with atopic derm avoid temp changes
minimize vasscular and sweat response
what triggers does a person with atopic derm have to avoid
evironmental
food
what meds are used to tx atopic derm
topical corticosteroids
topical immune modulators
nummular eczema lesions
coin shaped lesions
papulovesicular patches on arms and legs
what is normal for NE leision patterns
initial leisions heal, followed by secondary outbreak of mirror image leisons on opposite side of body
pattern of exacerbation for NE
chornic, with weeks and years between exacerbations. happens mostly in winter
tx for NE (lifestyle
avoid iodides and bromides
avoid frequent bathing and stress
inc environmental humidty
t
tx for NE (pharm)
topical emollients, corticosteroids, coal tar preperations, uv light
