Self Study 7 Flashcards
systemic lupus erythemaosus (SLE)
chronic inflm disease, major ruematic disease, can affect any organ system
which sex has inc predominance in SLE (with ratios)
10-1, 30-1 in child bearing years
which races have inc in sle
african, hispanic, asian, aboriginal
et sle
idiopathic genetic predispostion imbal in sex hormones UV light, food, infections agents drugs
which genes show a genetic link in SLE
hla-dr and hla-dq loci in MHC class II
which group of people has inc in genetic presdisopstion to sle
identical twins
which sex hormone imbal may cause sle
E
what drugs may cause sle
hydralazine
procainmaide
what is there inc prod of in SLE
Ab’s against self and non self ags
what type of cells are hyper active in SLE
B cells
what happens with an inc in Abs and B cell hyperactivity
direct damage to tissues or combine with other ags to form tissue damaging IC
what autoantibodies occur in SLE
antinucleur antibodies (ANA), antiDNA
what do androgens protect agains in Sle
estrogen favour development
what happens when esterogen favour dev occurs
imbalance
inc response in waht causes autoabs form
H imbal causes inc response from helper T cells
dec response of what causes autoabs to form
H imbal causes dec suppressor t cell
MS mnfts of sle
arthralgias and arthritis. eventual l/o fx of han
rupture of intrapatellar and achilles tendons
skin mnfts of sle
butterfly rash on nose and cheeks, fingertip lesions, nailfold infarct, splinter hemmorhage, hair loss, mucous memb lesions, sun sensitivty
what type of fingertip lesions form in sle
periungal erythema
renal mfnts of sle
glomerulonephritis, interstital nephritis, nephrotic sydrome
what may neprotic syndrome lead to
edema in legs, abd, face, RF
pulm mnfts of sle
pleural effusion, pleuritis, acute pneumonitis, pulm hemmr, chronic interstital lung disease
pulm embolism
CV mnfts of sle
pericarditis with pleural effusion, cardiac tamponade, congenital heart block in infants (mom has SLE), secondary HD, htn, ischemic HD, valvular lesions with ineffective endocarditis
CNS mfnts of sle
stroke, hemmorhage, IR that releases antineuronal Abs
seizures
depression and euphoria, dec cognition, altered LOC
why may stroke or hemmor occur as a cns mnft of sle
acute vasculitis
what do antinueronal abs attack
nerves, damage blood vessels
hematologic mfnts of sle
hemolytic anemia, leukopneia, lymphopenia, thrombocytopenia, plaque like lesions on head, scalp, neck
dx for sle
immunofloresence test for ANA. positive ana result may indicate disease.
antiDNA ab pressence
tx for sle
manage acute and chronic symtoms
prevent l/o organ fx, dec disability, prevent comps
what meds may be used to tx sle 5
nsaids antimalarial drugs corticosteroids immunosuppresives cyclosphamide
