Self Study 7

Question 1

systemic lupus erythemaosus (SLE)

Answer 1

chronic inflm disease, major ruematic disease, can affect any organ system

Question 2

which sex has inc predominance in SLE (with ratios)

Answer 2

10-1, 30-1 in child bearing years

Question 3

which races have inc in sle

Answer 3

african, hispanic, asian, aboriginal

Question 4

et sle

Answer 4

idiopathic
genetic predispostion
imbal in sex hormones
UV light, food, infections agents
drugs

Question 5

which genes show a genetic link in SLE

Answer 5

hla-dr and hla-dq loci in MHC class II

Question 6

which group of people has inc in genetic presdisopstion to sle

Answer 6

identical twins

Question 7

which sex hormone imbal may cause sle

Answer 7

E

Question 8

what drugs may cause sle

Answer 8

hydralazine

procainmaide

Question 9

what is there inc prod of in SLE

Answer 9

Ab’s against self and non self ags

Question 10

what type of cells are hyper active in SLE

Answer 10

B cells

Question 11

what happens with an inc in Abs and B cell hyperactivity

Answer 11

direct damage to tissues or combine with other ags to form tissue damaging IC

Question 12

what autoantibodies occur in SLE

Answer 12

antinucleur antibodies (ANA), antiDNA

Question 13

what do androgens protect agains in Sle

Answer 13

estrogen favour development

Question 14

what happens when esterogen favour dev occurs

Answer 14

imbalance

Question 15

inc response in waht causes autoabs form

Answer 15

H imbal causes inc response from helper T cells

Question 16

dec response of what causes autoabs to form

Answer 16

H imbal causes dec suppressor t cell

Question 17

MS mnfts of sle

Answer 17

arthralgias and arthritis. eventual l/o fx of han

rupture of intrapatellar and achilles tendons

Question 18

skin mnfts of sle

Answer 18

butterfly rash on nose and cheeks, fingertip lesions, nailfold infarct, splinter hemmorhage, hair loss, mucous memb lesions, sun sensitivty

Question 19

what type of fingertip lesions form in sle

Answer 19

periungal erythema

Question 20

renal mfnts of sle

Answer 20

glomerulonephritis, interstital nephritis, nephrotic sydrome

Question 21

what may neprotic syndrome lead to

Answer 21

edema in legs, abd, face, RF

Question 22

pulm mnfts of sle

Answer 22

pleural effusion, pleuritis, acute pneumonitis, pulm hemmr, chronic interstital lung disease
pulm embolism

Question 23

CV mnfts of sle

Answer 23

pericarditis with pleural effusion, cardiac tamponade, congenital heart block in infants (mom has SLE), secondary HD, htn, ischemic HD, valvular lesions with ineffective endocarditis

Question 24

CNS mfnts of sle

Answer 24

stroke, hemmorhage, IR that releases antineuronal Abs
seizures
depression and euphoria, dec cognition, altered LOC

Question 25

why may stroke or hemmor occur as a cns mnft of sle

Answer 25

acute vasculitis

Question 26

what do antinueronal abs attack

Answer 26

nerves, damage blood vessels

Question 27

hematologic mfnts of sle

Answer 27

hemolytic anemia, leukopneia, lymphopenia, thrombocytopenia, plaque like lesions on head, scalp, neck

Question 28

dx for sle

Answer 28

immunofloresence test for ANA. positive ana result may indicate disease. antiDNA ab pressence

Question 29

tx for sle

Answer 29

manage acute and chronic symtoms | prevent l/o organ fx, dec disability, prevent comps

Question 30

what meds may be used to tx sle 5

Answer 30

``` nsaids antimalarial drugs corticosteroids immunosuppresives cyclosphamide ```