Unit 11 Flashcards
lung ca
rt death by disease, mostly avoidable
mortality of lung ca
30%
characteristics of lung c
aggressive, invasive, metastic
where does lung c met to
brain, bones ,liver
4 primary types of lung ca
adenocarcinoma
squamous cell carcinoma
large cell carcinoma
small cell carcinoma
2 cats of primary lung ca
1 - not small cell lung ca
2 - small cell lung ca
what ca’s are in nsclc
adenocaracino
squamous cell carcinoma
large cell carcinoma
what cas are in sclc
small cell carcinoma
what is the 5th type of primary lung ca
mixed group
what percent of lug ca is adenocarcinoma
30
what percent of lung ca is squamous cell carcinoma
30
what percent of lung ca is large cell carcinoma
12
what percent of lung ca is small cell carcinoma
22
et of lung ca
smoking (80)
toxins (eg asbestos)
genetic predisposition
where does 95% of lung ca originate
bronchi
where does squamous cell carcinoma originate
hilum of central bronchi
where does squamous cell carcinoma spread
regionally to hilar nodes
who has increased dispostion to squamous cell carcinoma
men
what may tumor spread of squamous cell carcinoma cause
impact to pericardium -> dec heart fx
where does adenocarcinoma originate
peripherary
what is adenocarcinoma assoc with
alveoli and bronchioles
who has an increase in adenocarcinoma
women, non smokers
where does large cell carcinoma originate
peripheray
characteristics of large cell carcinoma
large, undifferentiated cells
mets early
which ca out of all nsclc has poorest prognisis
large cell carcinoma
characteristic of cells in small cell carcinoma
small, oval, oat like cells
which population experiences an increase in small cell carcinoma
99% smokers
characteristics of small cell carcinoma
aggressive, invasive with slim prognosis
where does small cell carcinoma met to early
brain
what percent of small cell carcinoma has mets at dx
70
what does small cell carcinoma do to local tissue
invades quickly
what is said about excision of small cell carcinoma
hard to excise, not resectable, cells may not be massed together
what tx does small cell carincoma have inc response to
radiation, said to be radiosensitive
what is a commone SE of small cell carcinoma
paraneoplastic syndrome
what conditions are included in paraneoplastic syndrome
SIADH (adh)
cushings (cortisol, adrenocortico)
what are mnfts of all lung ca’s based on
type, site, ext of local invasion, mets
central mnfts of lung ca
large aw obst, impaired breathing, unexplained coughing, wheezing, dyspnea
other mnfts of lung ca
paraneoplastic syndrome
hemoptysis
pain
cardiac mnfts
hemoptysis
coughing blood rt vessel damage caused by malignancy
cardiac mnfts in lung ca
rt inc P on heart. tumor has to affect pericardium, central malignancy only
dx for lung ca
hx, px rule out URT, CLD cxr, CT, US, MRI bronchophy/needle biopsy sputum analysis/ bronchiol wash
what is tx for lung ca basedo n
type
tx for nsclc
sx, radiation, chemo
tx for sclc
chemo radiation
why does lung ca have poor prognosis
no good screen -> dec detection
