Self study 5 Flashcards
2 types of tumors in renal ca
wilms tumor
renal cell carcinoma
2 types of tumors in renal ca
wilms tumor
renal cell carcinoma
when does wilms tumor usually present
peds age 2-5yo
what is wilms tumor composed of
elements that are similar to normal fetal tissue: blastemic, stromal, epithelial tissue
what congential abns is wilms assoc with
anridia
hemihypertrophy
other abns of GI
anridia
abesnce or iris
hemihypertrophy
enlargement of one side of face or body
what gene has a mutation that causes wilms
wilms tumor gene on chr 11
characteristics of wilms tumor
solitary mass, sharply demarcated and encapsulated in kindey.
grows to large size
stage 1 wilsm tumor
limited to kidney
can be excised
stage 2 wilms tumor
extend to renal capsule and can be excised
stage 3 wilms tumor
extend to abdomen
stage 4 wilms tumor
mets to lung
presentation wilsm tumor
lage asymsymptomatic abd mass, pain, vomiting, heamturia, htn
tx for wilms tumor
sx, chemo, radiatio
what percent of renal cell carcinoma is clear cell carcinoma
60%
what % of RCC is chromophobic tumor
5-10%
what % of RCC is onocytomas
5-10%
what % of RCC are collectiing duct tumors
characteristics of clear cell carcinoma
clear cytoplasm, chr 3 deletion, arise from proximal tubular cells
et RCC
tumors affect poles, mostly upper pole
unclear
risk factors for RCC
smoking
kidney cancer
obseity (esp women)
occupational exposure to petroleum, heavy metals, asbestor,
acquired cystic kidney disease assoc with renal insuff
mnfts of early RCC
silent in early stages. symptoms mean advanced
mnfts late RCC
hematuria, flank pain, presence of palpable flank mass
