Unit 23 Flashcards

1
Q

why is secondary bone ca (BCA) common

A

because of inc vascularity of bone -> inc blood moves here -> inc probablity of emboli to move thru bone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

where does most bone growth occur

A

metaphysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what does bone form from

A

cartildige

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

why is identification of primary bca hard

A

diverse types

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what do we identify bone ca based on

A

histology

location of ca in skeleton and in bone itself

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what type of tumor is osteosarcoma

A

bone forming

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

how common is osteosarcoma

A

most common

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

where does osteosarcoma usually originate (skeleton)

A

around knee

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

characteristics of mets in osteosarcoma

A

quick and easy, to lung

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what pts does 75% of osteosarcoma occur in

A

pts under 20

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

why does most osteosarcoma occur in young pts

A

dt inc cell prolif/dna replication that occurs prior to the halt of longitudinal bone growth at age 20. inc cell prolif-> inc risk of gene mutation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what pts does 25 % of osteosarcoma occur in

A

geri pts with underlying pathologic bone disease eg pagets

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

why does 25% of osteosarcoma occur in geri puts

A

pts with bone diseaes have inc resoprtion and formation of bone, this means there is still cell prolif/dna replication -> risk for gene mutatin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

other primary malignancies

A

chondrosarcoma
fibrosarcoma
others (ewings, osteoclastoma)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what percent of all ca mets to bone

A

50%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what percent of lung, breast and prostate ca’s met to bone

17
Q

what type of lesions are in 2 bca

A

lytic or blastic

18
Q

lytic lesion

A

space occupying lesion req destr of normal tissue

19
Q

blastic lesion

A

lesion uses space to build up

20
Q

what mnfts are common with secondary bone ca

A

pain rt inflm, swelling, fractures

21
Q

what is a major comp of secondary bone ca

22
Q

why do fractures occur in secondary bone ca

A

lytic lesions -> dec stress -> fracture

23
Q

what medical imaging is used to dx bone ca

A

xr (only with substantial mets, necrosis, breakdown)

ct mri

24
Q

what dx is used for bone ca

A

med imaging
biopsy
bone scan

25
fx of biopsy in bone ca
confirms malignancy and tells you the type (primary bca)
26
fx of bone scan in bone ca
may not be req, usually in secondary to confirm mets
27
tx for bca
chemo,radiation,sx pain tx prevent fractures
28
what type of sx is used in bca
block excision of bone then restorative grafting