Unit 12 Flashcards
where is CF restricted
to any exocrine gland
Et of CF
genetic
which gene is affected in CT
cystic fibrosis transmemb regulator gene
what chr is the CFTR gene on
7
what does cftr gene code for
cftr protein
characteristics of cftr
autosomal rescessive, monogenic
first step of patho in CF
cftr forms cl channel on epith wall -> cell memb is impermeable to cl
why is cl able to move from capiliarry into epithcell ok
cl moves from cap to cell via diffusion
where is the cl problem in cg
in the goblet cell, related to excretion of Cl out of cell
what happens when cl accumlates inside of the cell
inc concentration of cl inside cell
what happens to cells with inc cl concentrations
h20 enters cell to dec [cl]
what happens to Na in CF
it follows water back into the cl saturated cell
why is mucous in CF thick and sticky
dec h20 in mucous makes it thick and sticky - accum of mucociliary blanket
what happens to mucociliary clearance in CF
decreases
what type of environment devs in CF
environment that increases amount of microbial agents
