Unit 1.2c(iii) Flashcards
How do phosphates affect proteins?
They remove phosphate from r group, causing a confirmational change and therefore a change in the proteins activity
Where on an enzyme is the phosphate added?
It’s added to the -OH of certain R groups
How does the addition/removal of a phosphate regulate protein activity?
By causing a conformational change
What is protein kinases function?
Phosphorylation- catalyses the transfer of phosphate groups
Which phosphate group is transferred in phosphorylation?
The terminal phosphate from ATP
What proteins does phosphorylation regulate?
Receptors and enzymes
Are all proteins activated by phosphorylation?
No, some are inhibited
How does the addition of a phosphate group affect the proteins charge?
It gives it a negative charge
What does the addition of a phosphate group disrupt?
Unphosphorylated ionic interactions
What does phosphates catalyse?
Dephosphorylation
How does dephosphorylation change the proteins conformation?
It effects the charged interactions in the R group
What is phosphorylation a good example of?
Post-transitional modifications
