Types of collagen, synthesis, and diseases Flashcards

1
Q

Granulation tissue

A

III

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2
Q

OI results from impairement of:

A

Alpha triple helix formation during collagen synthesis

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3
Q

Skin

A

Mainly I, some III

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3
Q

What cofactor is required for hydroxylation of proline and lysine during collagen synthesis?

A

Vitamin C

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3
Q

In what form is collagen exocytosed into ECM during synthesis?

A

Procollagen (already in triple helix)

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3
Q

Most common type of Ehlers-Danlos?

A

Hypermobile type (joint instability)

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4
Q

Where is the alpha chain triple helix of precollagen formed?

A

RER of fibroblast

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5
Q

Cornea

A

I

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6
Q

Consensus sequence of collage

A

Gly-X-Y

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6
Q

Best reflection of collagen synthesis?

A

Glycine uptake by fibroblasts

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7
Q

Where is type IV collagen found?

A

Basement membrane, basal lamina, lens

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7
Q

What causes Menke disease?

A

Lack of copper transport and absorption –> no copper for lysyl oxidase cross-linking of lysine-hydroxylysine

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8
Q

Fascia

A

I

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9
Q

Where is type I collagen found?

A

Bone, skin, tendon, fascia, dentin, cornea, late wound repair

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10
Q

Kinky hair + growth retardation + hypotonia

A

Menke disease

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11
Q

Lens

A

IV

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11
Q

Which preprocollagen residues are hydroxylated in the RER of fibroblasts?

A

Proline and lysine

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12
Q

Uterus

13
Q

Where is type III collagen found?

A

Blood vessels, granulation tissue, fetal tissue, uterus, skin

13
Q

Hyperextensible skin + easy bruising/tendency to bleed + hypermobile joints

A

Ehlers-Danos

14
Q

Basement membrane

15
Q

Multiple fractures + hearing loss + dental imperfections

17
Q

Tendon

19
Q

Where is type II collagen found?

A

Cartilage (including hyaline), nucleus pulposus, vitreous body

19
Basal lamina
IV
21
Nucleus pulposus
II
22
Is type I collagen defective in OI?
No, just reduced production of otherwise normal type I collagen
23
Which residue of preprocollagen gets glycosylated in the RER of fibroblasts?
Hydroxylysine
24
Scurvy results in failure of which step of collagen synthesis?
Hydroxylation of proline and lysine in RER of fibroblast
26
Which type of collagen is underproduced in osteogensis imperfecta?
I
27
Name 5 diseases associated with collagen.
1. OI (no type I) 2. Ehlers-Danlos (no cross-linking) 3. Alport (defective IV) 4. Goodpasture's (autoantibodies against IV) 5. Menkes disease (no copper for lysyl oxidase)
29
Bone
I
30
Cartilage
II
32
Late wound repair
I
33
Risk of joint dislocation, aortic or berry aneurysms, organ rupture
Ehlers-Danlos
35
Blood vessels
III
36
Most common type of collagen
I
37
Which steps in collagen synthesis occur outside the fibroblast?
Cleave of terminal disulfide-bonds of procollagen to form tropocollagen Cross-linking of lysine-hydroxylysine
38
Dentin
I
40
Which enzyme cross-links collagen? What is its co-factor?
Lysyl oxidase Copper
41
Mode of inheritance: OI
AD
42
Fetal tissue
III
43
Vitreous body
II