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Step One R&M > Cancer associations, paraneoplastic syndromes > Flashcards

Cancer associations, paraneoplastic syndromes Flashcards

1
Q

CCl4

A

Centrilobular necrosis and fatty change of the liver

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1
Q

2nd leading cause of lung cancer

A

Radon

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1
Q

Antibodies against presynaptic Ca<span>2+</span> channels

A

Lambert-Eaton

Small cell carcinoma

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2
Q

EPO production

A
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2
Q

HPV

A

Cervical and penile cancer (16,18)

Throat or head and neck cancer

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3
Q

HHV-8

A

Kaposi sarcoma, body cavity fluid B cell lymphoma

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4
Q

XP, albinism

A

Melanoma, BCC, and especially squamous cell carcinoma of the skin

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6
Q

Aromatic amides

A

Transitional cell carcinoma

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6
Q

Cigarette smoke: lung

A

Squamous and small cell

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7
Q

Down syndrome

A

ALL, AML

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7
Q

Hypercalcemia

A

Squamous cell carcinoma (PTHrp)

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8
Q

Vinyl chloride

A

Angiosarcoma of liver

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9
Q

Barret esophagus

A

Adenocarcinoma of esophagus

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10
Q

Arsenic

A

Liver: Angiosarcoma

Lung: Lung cancer

Skin: Squamous cell carcinoma

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11
Q

Cushing syndrome

A

Small cell lung cancer

Increased ACTH

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12
Q

Autoimmune diseases

A

Lymphoma

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12
Q

Chronic atrophic gastritis, pernicious anemia, postsurgical gastric remnants

A

Gastric adenocarcinoma

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13
Q

HBV, HCV

A

HCC

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15
Q

Actinic keratosis

A

SCC of skin

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16
Q

Dermatomyositis

A

Lung cancer

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16
Q

Paget disease of bone

A

Secondary osteosarcoma and fibrosarcoma

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17
Q

Cigarette smoke: bladder

A

Transitional cell

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17
Q

Hypercalcemia

A

Lymphoma, usually Hodgkin’s

Increased vitamin D

18
Q

AIDS

A

Non-Hodgkins lymphoma, Kaposi sarcoma

19
Q

Cigarette smoke: kidney

A

Renal cell carcinoma

21
Q

Cirrhosis

23
Q

UC

A

Colonic adenocarcinoma

24
Q

MG, pure RBC aplasia

25
Q

Cushing syndrome

A

Small cell lung cancer

26
Q

Cigarette smoke: pancreas

A

Pancreatic adenocarcinoma

27
Q

Ionizing radiation: thyroid

A

Papillary carcinoma of the thyroid

27
Q

EBV

A

Burkitt lymphoma, nasopharyngeal carcinoma, CNS lymphoma, Hodgkin lymphoma

28
Q

Where do alfatoxins come from?

A

Aspergillus

30
Q

SIADH

A

Small cell lung cancer

32
Q

Polycythemia

A

Renal cell carcinoma, HCC

34
Q

Immunodeficiency states

36
Q

Asbestos

A

Bronchogenic carcinoma > mesothelioma

37
Q

Dysplastic nevus

38
Q

Radiation exposure

A

Leukemia, sarcoma, breast cancer, papillary thyroid cancer

38
Q

Cigarette smoke: larynx

A

Squamous cell carcinoma

39
Q

H. pylori

A

Gastric adenocarcinoma, MALToma

41
Q

Radon

A

Lung cancer

42
Q

PTHrP

A

Squamous cell carcinoma of the lung, renal cell carcinoma, breast cancer

Hypercalcemia

43
Q

Lambert-Eaton syndrome

A

Small cell cancer

45
Q

Acanthosis nigricans

A

Visceral malignancy, esp stomach

46
Q

Plummer-Vinson syndrome

A

Squamous carcinoma of esophagus

(PVS = dysphagia + glossitis + iron-deficiency anemia)

47
Q

Alkylating agents

A

Leukemias, lymphoma

48
Q

Increased ADH

A

Small cell lung cancer or intracranial tumors

SIADH

49
Q

Patient with MG has high hematocrit. Why?

A

Has a thymoma that’s producing EPO

50
Q

Tuberous sclerosis

A

Giant cell astrocytoma, renal cell angiomyolipoma, cardiac rhabdomyoma

51
Q

Nitrosamines

A

Gastric cancer

52
Q

Schistosoma haematobium

A

Squamous cell bladder cancer

53
Q

Aflatoxin

54
Q

HTLV-1

A

Adult T-cell lymphoma/leukemia

55
Q

Cigarette smoke: esophagus

A

Squamous cell/adenocarcinoma

Step One R&M (38 decks)

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