MHC's

Question 1

TAP protein

Answer 1

Transports endogenously synthesized antigen to RER to bind MHC class I

Question 2

ß2-microglobulin

Answer 2

Transports MHC class I with antigen to cell surface and stays bound to complex

Question 2

Where is MHC class II expressed?

Answer 2

APCs only

Question 3

Describe process of antigen loading via MHC class I

Answer 3

Antigen synthesized endogenously then transported to RER via TAP protein –> loaded onto MHC class I –> transported to cell surface via beta-2-microglobulin –> presented to C8+ T cells

Question 4

Loci of MHC I va MHC II

Answer 4

MHC I = HLA-A, HLA-B, HLA-C

MHC II = HLA-DR, HLA-DQ, HLA-DP

Question 4

Describe the process of antigen loading onto MHC class II

Answer 4

Removal of invariant chain of MHC class II in acidified endosome –> binding of exogenously synthesized protein –> transport to cell surface

Question 6

Presents endogenously synthesized antigens

Answer 6

MHC I (aka virus)

Question 8

Where is MHC class I expressed?

Answer 8

All nucleated cells except RBCs

Question 9

Only cells in body that don’t express MHC class I?

Answer 9

RBCs

Question 10

Binding of MHC class I

Answer 10

TCR and CD8+

Question 11

Binding of MHC class II

Answer 11

TCR and CD4+

Question 12

Presents exogenously synthesized protein

Answer 12

MHC class II (bacterial, viral caspid)