Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Step One R&M > Oncogenes, tumor suppressor genes, and tumor markers > Flashcards

Oncogenes, tumor suppressor genes, and tumor markers Flashcards

1
Q

What is the function of VHL?

A

Inhibits hypoxia-inducible factor 1a

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Serine-threonine kinase

A

BRAF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is p53 normal function?

A

Transcription factor for p21, which inhibits G1–>S

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

In which cancer is DCC mutated and what is the gene product?

A

CRC

DCC (deleted in colon cancer)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

In which cancer is p16 mutated and what is the gene product?

A

Melanoma

Cyclin-dependent kinase inhibitor 2A

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Hairy cell leukemia

A

TRAP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Inhibits HIF1a

A

VHL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

In what cancer is BRAF mutated and what is the gene product?

A

Melanoma

Seronine-threonine kinase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Cytokine receptor

A

c-kit

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

In which cancer is bcl-2 mutated and what is the gene product?

A

Follicular and undifferentiated carcinomas

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

In which cancer is BCR-ABL mutated and what is the gene product?

A

CML, ALL

Tyrosine kinase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

AFP

A

HCC, yolk sac tumor, mixed germ cell tumors, testicular cancer, hepatoblastoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Neuroblastoma

A

N-myc

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Colon, lung, and pancreatic cancer

A

RAS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Calcitonin

A

Medullary carcinoma of the thyroid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

In which cancer is NF1 mutated and what is the gene product?

A

Neurofibromatosis 1

RAS GTPase activating protein (neurofibromin)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

TRAP

A

Hairy cell leukemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Tyrosine kinases

A

BCR-ABL

HER2/neu

ret

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

GTPase

A

ras

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Breast, ovarian, gastric cancer

A

HER2/neu

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Follicular and undifferentiated lymphomas

A

bcl-2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

MEN 2A and 2B

A

RET

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

In which cancer is ret mutated and what is the gene product?

A

MEN 2A and 2B

Tyrosine kinase

19
Q

In which cancers is Rb mutated and what is the gene product?

A

Retinoblastoma and osteosarcoma

Rb protein inhibits E2F so blocks G1–>S

20
Anti-apoptotic molecule
bcl-2
21
CA-125
Ovarian cancer
22
Tumor marker for medullary carcinoma of the thyroid
Calcitonin
24
S-100
Neural tumors, Schwannoma, Langerhans histiocytosis, melanoma
25
Lung cancer
L-myc
26
CA-15-3/CA-27-29
Breast cancer
27
Transcription factors
c-myc N-myc L-myc
29
In which cancer is NF2 mutated and what is the gene product?
Neurofibromatosis 2 Merlin (schwannomin) protein
31
Burkitt lymphoma
c-myc
32
CA-19-9
Pancreatic cancer
33
Tumor marker for breast cancer
CA-15-3/CA-27-29
35
DNA repair proteins
BRCA1 and BRCA2
36
In which cancer is c-kit mutated and what is the gene product?
GIST Cytokine receptor for stem cell factor
37
CML, ALL
BCR-ABL
38
AFP + ß-hCG
Mixed germ cell tumor
39
In which cancer is CPD4/SMAD4 mutated and what is the gene product?
Pancreatic cancer DPC (deleted in pancreatic cancer)
40
GIST
c-kit
41
In which cancer is c-myc mutated and what is the gene product?
Burkitt lymphoma Transcription factor
41
Colon cancer
ras (GTPase) DCC (TSG)
42
Tumor marker for ovarian cancer
CA-125
43
Two tumor suppressor genes which normally inhibit G1--\>S
p53 (transcription factor for p21) Rb (inhibits E2F)
44
ß-hCG
Choriocarcinoma, hydatidiform mole, testicular cancer
45
Pancreatic cancer
ras (GTPase) CPD4/SMAD4 (DPC)
47
Tumor marker for pancreatic cancer
CA-19-9
48
In which cancers is HER2/neu mutated and what is the gene product?
Breast, ovarian, and gastric cancers Tyrosine kinase
49
Melanoma
BRAF (oncogene) and p16 (TSG)
50
Breast, prostate, endometrial cancer
PTEN
51
In which cancer is N-myc mutated and what is the gene product?
Neuroblastoma Transcription factor
53
In which cancers is ras mutated and what is the gene product?
Colon, lung, pancreatic cancer GTPase
54
In which cancer is L-myc mutated and what is the gene product?
Lung cancer Transcription factor
55
CEA
CRC, pancreatic cancer, medullary carcinoma of the thyroid, gastric cancer, breast cancer

Step One R&M (38 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions