Autoantibodies Flashcards

1
Q

Goodpasture’s

A

Anti-BM

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1
Q

Anti-hemidesmosome

A

Bullous pemphigoid

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1
Q

p-ANCA

A

Anti-MPO

Microscopic polyangitis, Churg-Strauss

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2
Q

Type I DM

A

Anti-glutamate decarboxylase

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3
Q

Dermatomyositis, polymyositis

A

Anti-Jo, anti-SRP, anti-Mi-2

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4
Q

Celiac disease

A

IgA antiendomysial

IgA anti-tissue transglutaminase

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5
Q

MG

A

Anti-ACh receptor

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5
Q

Anti-dsDNA

A

SLE

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5
Q

Bullous pemphigoid

A

Anti-hemidesmosome

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6
Q

Causes of anti-histone antibodies in blood

A

Drug-induced lupus due to procainamide, hydralazine, and INH

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7
Q

Autoimmune hepatitis

A

Anti-smooth muscle

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8
Q

Anti-TSH receptor

A

Grave’s

(antibody STIMULATES receptor = hyperthyroidism)

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8
Q

Anti-MPO

A

p-ANCA

Microscopic polyangitis

Churg-Strauss

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9
Q

Anti-thyroglobulin

A

Hashimoto

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10
Q

What effect does lupus anticoagulant have on coagulation studies?

A

Falsely-elevated PTT

(but patient is acutally hypercoagulated)

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11
Q

Drug-induced lupus

A

Antihistone

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12
Q

Mixed connective tissue disease

A

Anti-U1 RNP

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13
Q

Anti-U1 RNP

A

Mixed connective tissue disease

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15
Q

Anti-ACh receptor

A

MG

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16
Q

IgA anti-tissue transglutaminase

A

Celiac disease

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17
Q

Graves disease

A

Anti-TSH receptor

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18
Q

Sjogren’s

A

Anti-Ro, anti-La

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19
Q

Anti-centromere

19
Q

Anti-La

A

Sjogren’s

20
Antimicrosomal
Hashimoto
21
IgA antiendomysial
Celiac disease
22
c-ANCA
anti-PR3 Wegner's
23
Hashimoto
Anti-microsomal, anti-thyroglobulin
24
Anti-IgG Fc
Rheumatoid factor
25
SLE
Antinuclear antibodies, Anti-Smith, Anti-dsDNA, Anti-cardiolipin
27
Scleroderma
Anti-DNA topoisomerase I
28
Anti-CCP
RA
29
What effect does anti-cardiolipin antibody have on syphilis testing?
False +
30
Antimitochondrial
Primary biliary cirrhosis
31
What is the clinical consequence of finding lupus anticoagulant in a patient's blood?
Must be put on life-long anticoagulant
33
Anti-desmoglein
Pemphigus vulagaris
34
Anti-DNA topoisomerase I
Scleroderma ( = Scl-70 )
35
Antihistone
Drug-induced lupus
36
CREST
Anti-centromere
37
Anti-Smith
SLE
38
Churg Strauss
Anti-MPO/p-ANCA
40
Anti-cardiolipin or lupus anticoagulant
SLE, antiphospholipid syndrome
41
Pemphigus vulgaris
Anti-desmoglein
42
What is the target of Sjogren antibodies?
Ribonucleoproteins (anti-SSA, anti-SSB, anti-Ro, anti-La)
44
Anti-smooth muscle
Autoimmune hepatitis
46
Anti-Jo
Dermatomyositis, polymyositis
47
Anti-PR3
cANCA Wegner's
48
Most specific for SLE
Anti-dsDNA
49
Primary biliary cirrhosis
Anti-mitochondrial
50
Anti-BM
Goodpasture syndrome
51
Wegner's
c-ANCA/anti-PR3
52
RA
Anti-CCP (specific), rheumatoid factor (IgM against Fc of IgG)
53
Anti-Ro
Sjogren's
54
Anti-Mi-2
Dermatomyositis, polymyositis
55
Anti-glutamate decarboxylase
Type I DM
56
Anti-SRP
Dermatomyositis, polymyositis