Autoantibodies

Question 1

Goodpasture’s

Answer 1

Anti-BM

Question 1

Anti-hemidesmosome

Answer 1

Bullous pemphigoid

Question 1

p-ANCA

Answer 1

Anti-MPO

Microscopic polyangitis, Churg-Strauss

Question 2

Type I DM

Answer 2

Anti-glutamate decarboxylase

Question 3

Dermatomyositis, polymyositis

Answer 3

Anti-Jo, anti-SRP, anti-Mi-2

Question 4

Celiac disease

Answer 4

IgA antiendomysial

IgA anti-tissue transglutaminase

Question 5

MG

Answer 5

Anti-ACh receptor

Question 5

Anti-dsDNA

Answer 5

SLE

Question 5

Bullous pemphigoid

Answer 5

Anti-hemidesmosome

Question 6

Causes of anti-histone antibodies in blood

Answer 6

Drug-induced lupus due to procainamide, hydralazine, and INH

Question 7

Autoimmune hepatitis

Answer 7

Anti-smooth muscle

Question 8

Anti-TSH receptor

Answer 8

Grave’s

(antibody STIMULATES receptor = hyperthyroidism)

Question 8

Anti-MPO

Answer 8

p-ANCA

Microscopic polyangitis

Churg-Strauss

Question 9

Anti-thyroglobulin

Answer 9

Hashimoto

Question 10

What effect does lupus anticoagulant have on coagulation studies?

Answer 10

Falsely-elevated PTT

(but patient is acutally hypercoagulated)

Question 11

Drug-induced lupus

Answer 11

Antihistone

Question 12

Mixed connective tissue disease

Answer 12

Anti-U1 RNP

Question 13

Anti-U1 RNP

Answer 13

Mixed connective tissue disease

Question 15

Anti-ACh receptor

Answer 15

MG

Question 16

IgA anti-tissue transglutaminase

Answer 16

Celiac disease

Question 17

Graves disease

Answer 17

Anti-TSH receptor

Question 18

Sjogren’s

Answer 18

Anti-Ro, anti-La

Question 19

Anti-centromere

Answer 19

CREST

Question 19

Anti-La

Answer 19

Sjogren’s

Question 20

Antimicrosomal

Answer 20

Hashimoto

Question 21

IgA antiendomysial

Answer 21

Celiac disease

Question 22

c-ANCA

Answer 22

anti-PR3

Wegner’s

Question 23

Hashimoto

Answer 23

Anti-microsomal, anti-thyroglobulin

Question 24

Anti-IgG Fc

Answer 24

Rheumatoid factor

Question 25

SLE

Answer 25

Antinuclear antibodies, Anti-Smith, Anti-dsDNA, Anti-cardiolipin

Question 27

Scleroderma

Answer 27

Anti-DNA topoisomerase I

Question 28

Anti-CCP

Answer 28

RA

Question 29

What effect does anti-cardiolipin antibody have on syphilis testing?

Answer 29

False +

Question 30

Antimitochondrial

Answer 30

Primary biliary cirrhosis

Question 31

What is the clinical consequence of finding lupus anticoagulant in a patient’s blood?

Answer 31

Must be put on life-long anticoagulant

Question 33

Anti-desmoglein

Answer 33

Pemphigus vulagaris

Question 34

Anti-DNA topoisomerase I

Answer 34

Scleroderma

( = Scl-70 )

Question 35

Antihistone

Answer 35

Drug-induced lupus

Question 36

CREST

Answer 36

Anti-centromere

Question 37

Anti-Smith

Answer 37

SLE

Question 38

Churg Strauss

Answer 38

Anti-MPO/p-ANCA

Question 40

Anti-cardiolipin or lupus anticoagulant

Answer 40

SLE, antiphospholipid syndrome

Question 41

Pemphigus vulgaris

Answer 41

Anti-desmoglein

Question 42

What is the target of Sjogren antibodies?

Answer 42

Ribonucleoproteins

(anti-SSA, anti-SSB, anti-Ro, anti-La)

Question 44

Anti-smooth muscle

Answer 44

Autoimmune hepatitis

Question 46

Anti-Jo

Answer 46

Dermatomyositis, polymyositis

Question 47

Anti-PR3

Answer 47

cANCA

Wegner’s

Question 48

Most specific for SLE

Answer 48

Anti-dsDNA

Question 49

Primary biliary cirrhosis

Answer 49

Anti-mitochondrial

Question 50

Anti-BM

Answer 50

Goodpasture syndrome

Question 51

Wegner’s

Answer 51

c-ANCA/anti-PR3

Question 52

RA

Answer 52

Anti-CCP (specific), rheumatoid factor (IgM against Fc of IgG)

Question 53

Anti-Ro

Answer 53

Sjogren’s

Question 54

Anti-Mi-2

Answer 54

Dermatomyositis, polymyositis

Question 55

Anti-glutamate decarboxylase

Answer 55

Type I DM

Question 56

Anti-SRP

Answer 56

Dermatomyositis, polymyositis