Txt MI: Necrosis Flashcards
What is the goal of necrosis management?
↓ work of heart to reduce ischemia and anoxia; target clot interrupting coronary blood flow
Focus on minimizing myocardial damage and preserving heart function.
What type of drug is Propranolol?
Non-selective β blocker
It blocks both β₁ and β₂ receptors.
What is the main effect of Propranolol?
Reduces heart rate and myocardial oxygen demand, thus limiting infarct size
Useful in post-MI management to reduce further necrosis and angina.
What are the risks associated with Propranolol?
Bradycardia, hypotension, and bronchospasm
Especially concerning in patients with asthma or reactive airway disease.
What is tPA (Tissue Plasminogen Activator)?
Fibrinolytic agent
Used to dissolve thrombi and restore blood flow.
What is the mechanism of action of tPA?
Converts inactive plasminogen to plasmin, catalyzing depolymeration of fibrin
This process dissolves thrombi and restores blood flow.
What is the indication for tPA?
STEMI thrombolysis
Administered to patients experiencing ST-Elevation Myocardial Infarction.
What is a significant risk of using tPA?
High bleeding risk, especially in brain and GI tract
Monitoring for complications is critical.
What is the MoA of Urokinase?
Fibrinolytic agent
Directly activates plasminogen to promote clot breakdown.
What is the indication for Urokinase?
Thrombolytic therapy in MI
Used in the management of myocardial infarction.
What are the risks associated with Urokinase?
Bleeding complications and hypotension
Proper dosing and monitoring for hemorrhagic events are essential.
What type of drug is Streptokinase?
Fibrinolytic agent
What is the mechanism of action of Streptokinase?
It forms an activator complex with plasminogen, enhancing conversion of plasminogen to plasmin, which lyses clots
Utilized in thrombolysis during acute myocardial infarction.
What are the risks of using Streptokinase?
Allergic reactions and bleeding
Contraindicated in patients with recent streptococcal infections.
What is the difference btwn tPA, urokinase, and streptokinase?
tPa: converts inactive plasminogen to plasmin
urokinase: directly activates plasminogen to plasmin
streptokinase: forms an activator complex w/plasminogen
