Enhancers of sympathetic outflow

Question 1

What type of inhibitor is selegiline?

Answer 1

MAO-B inhibitor

Selegiline inhibits monoamine oxidase-B, which increases dopamine and other catecholamines levels.

Question 2

What is the primary use of selegiline?

Answer 2

Parkinson’s disease; adjunct in depression

Selegiline is used primarily for managing Parkinson’s disease and as an adjunct treatment in depression.

Question 3

What are common side effects of selegiline?

Answer 3

Insomnia, nausea, potential drug interactions

Insomnia and nausea are common side effects, and there is a risk of drug interactions.

Question 4

What type of inhibitor is tolcapone?

Answer 4

COMT inhibitor

Tolcapone inhibits catechol-O-methyltransferase, which prolongs the effects of L-Dopa.

Question 5

What is the primary use of tolcapone?

Answer 5

Adjunct therapy in Parkinson’s disease

Tolcapone is used as an adjunct therapy in the treatment of Parkinson’s disease.

Question 6

What significant risk is associated with tolcapone?

Answer 6

Hepatotoxicity risk; requires periodic liver function monitoring

Tolcapone poses a risk of hepatotoxicity, necessitating regular monitoring of liver function.

Question 7

What is the MoA of selegiline?

Answer 7

Inhibits monoamine oxidase-B, increasing dopamine (and other catecholamines) levels

Question 8

What is the MoA of tolcapone (Tasmar)?

Answer 8

Inhibits catechol-O-methyltransferase, prolonging the effect of L-Dopa