Indirect and Mixed-Acting Sympathomimetics Flashcards
What type of drug is Amphetamine (Adderall)?
Indirect sympathomimetic
Increases release of NE, DA, and 5-HT; inhibits reuptake.
What conditions is Amphetamine (Adderall) used to treat?
ADHD, narcolepsy
CNS stimulant to treat narcolepsy; stimulant in elderly.
What are some side effects of Amphetamine (Adderall)?
Insomnia, appetite suppression, hypertension, potential for abuse
What is the MoA of adderall?
Increases release of NE, DA, and 5-HT; inhibits reuptake
displaces catecholamines from storage vesicles and results in increased NE in the synapse
What type of drug is Dextroamphetamine (Dexedrine)?
Indirect sympathomimetic
Increases release of NE, DA, and 5-HT.
What conditions is Dextroamphetamine (Dexedrine) used to treat?
ADHD, narcolepsy
Increases release of NE, DA, and 5-HT.
What should be monitored when using Dextroamphetamine (Dexedrine)?
Cardiovascular status and risk for abuse
What type of drug is Methylphenidate (Ritalin)?
Indirect sympathomimetic
Increases catecholamine availability by blocking reuptake.
What conditions is Methylphenidate (Ritalin) used to treat?
ADHD, narcolepsy
Increases catecholamine availability by blocking reuptake.
What are some side effects of Methylphenidate (Ritalin)?
Insomnia, decreased appetite, increased heart rate, potential for abuse
What type of drug is Atomoxetine (Strattera®)?
NE reuptake inhibitor (NRI/NERI)
Inhibits norepinephrine reuptake, increasing synaptic NE levels.
What condition is Atomoxetine (Strattera®) used to treat?
ADHD
Inhibits norepinephrine reuptake, increasing synaptic NE levels.
What are some side effects of Atomoxetine (Strattera®)?
Gastrointestinal upset, decreased appetite, potential suicidal ideation in pediatric/adolescent populations
What type of drug is Ephedrine?
Indirect acting sympathomimetic and weak a1 and b2 AR agonist (mixed actions)
Increases release of NE into synapses and directly stimulates α1 and β2 receptors.
What is the MoA of Ephedrine?
Increases release of NE into synapses and directly stimulates α1 and β2 receptors.
What condition is Ephedrine commonly used to treat?
Nasal congestion, mild hypotension
What are some potential side effects of Ephedrine?
Insomnia, tachycardia, hypertension; caution in patients with cardiovascular disease
Fill in the blank: Amphetamine (Adderall) increases release of _______.
NE, DA, and 5-HT
True or False: Atomoxetine (Strattera®) has a potential for abuse.
False
Fill in the blank: Methylphenidate (Ritalin) increases catecholamine availability by _________.
blocking reuptake
