Direct acting cholinolytics Flashcards
What is the mechanism of action of atropine?
Mechanism of action: competitive muscarinic cholinergic receptor antagonists
Binds to the muscarinic cholinergic receptor in the target tissue and blocks the action → decreased PNS response
cholinolytic = anticholinergic = cholinergic receptor antagonist
What type of drug is atropine?
Anticholinergic muscarinic antagonist
cholinolytic = anticholinergic = cholinergic receptor antagonist
Blocks muscarinic receptors, reducing parasympathetic tone.
List three indications for atropine.
- Induces mydriasis (dilation)
- Reduces secretions
- Treatment of ventricular bradycardia
- Treatment of severe diarrhea and urinary bladder incontinence
Not commonly used for diarrhea or urinary incontinence due to systemic side effects.
What is the MoA of scopolamine?
Inhibits muscarinic receptors to decrease secretions and vestibular stimulation
What is scopolamine classified as?
Muscarinic antagonist
cholinolytic = anticholinergic = cholinergic receptor antagonist
Inhibits muscarinic receptors to decrease secretions and vestibular stimulation.
What are the uses of scopolamine?
- Treatment of motion sickness
- Overactive bladder (OAB; detrusor instability or overactivity)
Affects up to 33% of the US population.
What is the MoA of solifenacin (Vesicare)?
is a selective M3 muscarinic cholinergic receptor antagonist that reduces PNS control over the contractile state of the detrusor muscle that lines the urinary bladder
What are common side effects of scopolamine?
Drowsiness, dry mouth, blurred vision
Caution in elderly patients and those with glaucoma.
What is solifenacin (Vesicare)?
Selective M3 cholinergic receptor antagonist
cholinolytic = anticholinergic = cholinergic receptor antagonist
Reduces PNS control over the contractile state of the detrusor muscle that lines the urinary bladder.
What condition does solifenacin primarily treat?
Overactive bladder (OAB; detrusor instability or overactivity)
Affects up to 33% of the US population.
List common side effects of solifenacin.
- Dry mouth
- Constipation
- Blurred vision
Monitor for urinary retention.
What is tolterodine classified as?
Muscarinic antagonist
cholinolytic = anticholinergic = cholinergic receptor antagonist
Blocks muscarinic receptors in the bladder, decreasing urgency and frequency.
What condition is tolterodine used to treat?
Overactive bladder
It decreases urgency and frequency of urination.
What are common side effects of tolterodine?
- Dry mouth
- Constipation
- Dizziness
Use cautiously in patients with narrow-angle glaucoma.
