"Combined/ Generalized Sympatholytics" Flashcards
1
Q
What type of antagonist is labetalol?
A
Both A and B antagonist
2
Q
What is the primary effect of labetalol on cardiac output?
A
Reduces cardiac output (B1 AR ant)
3
Q
How does labetalol affect the compensatory vasomotor response?
A
Blocks compensatory vasomotor response by blocking A1 AR in peripheral vascular system
4
Q
What are the indications for using labetalol?
A
Hypertensive emergencies (including in pregnancy)
5
Q
What are potential side effects of labetalol?
A
Orthostatic hypotension, bradycardia
6
Q
What is required when administering labetalol, particularly in pregnant patients?
A
Careful titration required
7
Q
What is the overall MoA of labetalol?
A
reduces cardiac output (B1 AR ant) and blocks compensatory vasomotor response by blocking A1 AR in peripheral vascular system
