Novel AntiHTN Agents

Question 1

What is Nesiritide?

Answer 1

A BNP analog that mimics B-type natriuretic peptide

Question 2

What are the effects of Nesiritide?

Answer 2

Decreases renin/aldosterone release,

decreases blood volume, cardiac output, and total peripheral resistance,

promoting vasodilation, natriuresis, and diuresis

mimics B-type natriuretic peptide

Question 3

What condition is Nesiritide used to treat?

Answer 3

Acute decompensated heart failure, hypertension

Question 4

What are the side effects of Nesiritide?

Answer 4

Hypotension, headache

Question 5

What is Bosentan?

Answer 5

An endothelin receptor antagonist

Question 6

How does Bosentan function?

Answer 6

Blocks endothelin-1 receptors to reduce vasoconstriction

Question 7

What condition is Bosentan used to treat?

Answer 7

Pulmonary arterial hypertension

Question 8

What are the side effects of Bosentan?

Answer 8

Hepatotoxicity, peripheral edema

Question 9

What monitoring is required when using Bosentan?

Answer 9

Regular liver function monitoring