Selective β AR Sympathomimetics Flashcards
What type of agonist is isoproterenol?
Non-selective β agonist
Stimulates β1, β2, and β3 receptors
What conditions can isoproterenol be used to treat?
Bradycardia, heart block, sometimes asthma
Use cautiously in patients with coronary artery disease
What are the potential side effects of isoproterenol?
Tachycardia, arrhythmias, myocardial ischemia
Use cautiously in patients with coronary artery disease
What type of agonist is dobutamine?
Selective B1 AR agonist
Selectively stimulates β1 receptors to enhance cardiac contractility
What is dobutamine primarily used for?
Heart failure, cardiogenic shock
Requires close cardiac monitoring
What are the potential side effects of dobutamine?
Tachycardia, arrhythmias, hypertension
Requires close cardiac monitoring
What type of agonist is albuterol?
Selective B2 agonist
Stimulates β2 receptors leading to bronchodilation
What conditions can albuterol be used to treat?
Asthma, COPD
Less polar, more lipid soluble, able to pass BBB and cause central effects
What are the potential side effects of albuterol?
Tremors, tachycardia, nervousness
Less polar, more lipid soluble, able to pass BBB & cause central effects
Monitor for paradoxical bronchospasm in some patients
What type of agonist is terbutaline?
Selective B2 agonist
Activates β2 receptors causing bronchodilation and uterine relaxation
What is terbutaline primarily used for?
Asthma; tocolysis in preterm labor
What are the potential side effects of terbutaline?
Tachycardia, tremors, hyperglycemia
Less polar, more lipid soluble, able to pass BBB and cause central effec
Caution in diabetic patients
What type of agonist is mirabegron?
Selective B3 AR agonist
Stimulates β3 receptors in the detrusor muscle of the bladder, relaxing it
What condition can mirabegron be used to treat?
Overactive bladder
Stimulates β3 receptors in the detrusor muscle of the bladder, relaxing it
What are the potential side effects of mirabegron?
Hypertension, nasopharyngitis
Monitor blood pressure and urinary function
