tuberculosis part 1 Flashcards
what is the first line of treatment for TB ?
isoniazid pyrazinamide ethambutol rifampicin streptomycin
what is the mechanism of action of rifampicin ?
inhibition RNA synthesis
what is the mechanism of action of isoniazid and ethambutol ?
they both inhibit cell wall synthesis
isoniazid- lipid aspect
ethambutol- protein aspect
what is the mechanism of action of streptomycin ?
inhibition of protein synthesis
what is the standard treatment regimen ?
through the intensive phase
continuation phase
continuous phase
what is the purpose of the intensive phase ?
rapidly kill of the dividing organisms
What is the purpose of the continuation phase ?
to sterilize the lungs by killing dormant and semidormant organsims to prevent relapse
what medications are taken in the intensive phase ?
2 months of all 4
2 months of rifampcin and isoniazid
what medications are taken in the continuation phase
4 months of isoniazid and rifampicin
how often should the drugs be administered ?
3 times per week
how is the monitoring of the TB case done ?
clinical
microbiological response
lab response
what does the clinical monitoring include?
general condition
fever
appetite
screening for common side effects
how is the microbiological response monitored ?
sputum at 2 months
sputum at completion of therapy
sputum at completion of therapy
how is the lab response monitored ?
first 2 weeks; twice weekly (( 4 total ))
at 1 month then monthly
AST ,ALT, bilirubin and CBC
if there are skin rashes what should be stopped ?
stop anti-tb drugs
if there is deafness or dizziness what should be stopped ?
streptomycin