cardiomyopathies and myocarditis Flashcards
what is the most common cardiomyopathy ?
dilated congestive cardiomyopathy (DCM)
what is the pathology in dilated cardiomyopathy ?
progressive dilatation of all chambers , a big heart with very big chambers
what type of dysfunction is associated with dilated cardiomyopathy ?
systolic dysfunction
what are the causes of dilated cardiomyopathy ?
non genetic
genetic
idiopathic
what are the causes of DCM?
a bunch of stuff can cause cardiac dilatation
Alcohol abuse
Beriberi
Coxsackie
Cocaine
Chagas disease
Doxorubicin
peripartum cardiomyopathy
takutsobo cardiomyopathy
tachycardia cardiomyopathy
what are the genetic causes of DCM ?
Duchenne and Becker muscular atrophy
what are the treatments of DCM ?
conventional management of heart failure with thee option of cardiac resynchronization therapy and ICDs for patients with a score 3 in thee NYHA
cardiac transplantation
what is the pathology in hypertrophic cardiomyopathy ?
-massive myocardial hypertrophy without ventricular dilatation ( asymmetrical hypertrophy of the interventricular septum )
what is the echo finidings in hypertrophic cardiomyopathy ?
banana like ventricular cavity
what type of dysfunction is associated with HCM?
diastolic dysfunction
what is the gross picture of HCM ?
asymmetrical septal hypertrophy
asymmetrical left ventricular hypertrophy
what are the causes of HCM ?
distinct genetic disorder, where there is a defect in one of the genes encoding cardiac contractile proteins
is also a storage disease found in babies to diabetic mothers
what are the genes affected in HCM?
heavy chain myosin
what are the effects of HCM
commonest cause of sudden cardiac death in young during vigorous exercise
syncopal attacks on exercise
what is the treatment for HCM?
according to risk stratification
ICD insertion for patients with high risk of sudden death
risk is lower ? amiodarone
what is the most common cause of sudden death in adolescent during vigorous exercise ?
hypertrophic cardiomyopathy
what is the pathology in restrictive cardiomyopathy ?
infiltration of the myocardium resulting in a firm myocardium and eventually failure of relaxation
what are the causes of restrictive cardiomyopathy ?
RASH
radiation fibrosis
amyloidosis
sarcoidosis
hemochromatosis
what is amyloidosis ?
extracellular deposition of amyloid substance mainly of walls of blood vessels
what stain can be used with amyloid ?
congo red stain
what is seen on clinical examination with restrictive cardiomyopathy ?
1- elevated JVP with diastolic collapse - friedreich’s sign
2- elevation of venous pressure with inspiration (Kussmmaul’s sign )
right ventricular hypertrophy
what is the treatment of restrictive cardiomyopathy ?
medical
prevention of progression
cardiac transplantation