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ICC1 > clinical therapeutics pulmonology > Flashcards

clinical therapeutics pulmonology Flashcards

1
Q

what are the two types of histamine1 blockers ?

A

first generation

second generation

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2
Q

what is the clinical use of FG H1 blockers ?

A

allergy
motion sickness
sleeping aid

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3
Q

what are the adverse effects of first generation H1 blockers ?

A

sedation
antimuscarinic
anti alpha adrenergic ( vasoconstriction)

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4
Q

what is the clinical use of second generation H1 blockers ?

A

allergy

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5
Q

which type of H1 blocker has a more potent sedation effect ?

A

H1 blocker

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6
Q

if a patient presents with COPD along with secretions what could be given ?

A

muscarinic antagonists

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7
Q

what is an example of an expectorant ?

A

guaifenesin

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8
Q

what is the effect of guaifenesin ?

A

it is an expectorant that does not suppress cough reflex

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9
Q

what is an example of a mucolytic ?

A

n-acetylcysteine

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10
Q

what are the other uses of n-acetylcysteine ?

A

antidote for paracetamol poisoning

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11
Q

what is the mechanism of action of n-acetylcysteine ?

A

breaks sulphide bonds

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12
Q

what is an example of an antitussive agent ?

A

dextromethorphan

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13
Q

what is the mechanism of action dextromethopran ?

A

synthetic codeine analogue

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14
Q

what can be given for dextromethopran overdose ?

A

naloxone

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15
Q

what are the adverse side effects of dextromethopran ?

A

serotonin syndrome if combined with serotonergic agents

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16
Q

when is it not advised to use dextromethorpran ?

A

in a productive cough patient but more in ann irritating dry cough

17
Q

what is an example of an alpha adrenergic agonists ?

A

pseudoephedrine

18
Q

what is the clinical use of pseudoephedrine ?

A

nasal decongestant

19
Q

what is the adverse effect of pseudoephedrine ?

A

rebound congestion

20
Q

when should pseudoephedrine be avoided ?

A

hypertensive patient

21
Q

what are the pulmonary hypertensive drugs ?

A

endothelin receptor antagonists
PDE-5 inhibitors
Prostacyclin analogue

ICC1 (50 decks)

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