TRYPSIN

Question 1

Where is trypsin solely produced?

Answer 1

Acinar cells

Question 2

Cleaves peptide bonds formed between the -COOH
group of lysine or arginine with other amino acids

Answer 2

Trypsin

Question 3

trypsinogen- & trypsinogen-2

Answer 3

Zymogen

Question 4

What is the activator of trypsin?

Answer 4

Enterokinase

Question 5

Trypsin is inactivated by?

Answer 5

a-1 antitrypsin
a-2-
macroglobulin

Question 6

What is the charge classification of trypsin 1 and 2?

Answer 6

TRYPSIN-1 (Cationic)
TRYPSIN-2 (Anionic)

Question 7

Where is trypsin 1 elevated?

Answer 7

Acute Pancreatitis
Chronic Renal failure
Cystic Fibrosis

Question 8

Explain why trypsin 1 is elevated in acute pancreatitis.

Answer 8

TRY-1 rises in parallel
with serum AMY activity

Question 9

Serum trypsinogen-2 increases
more than trypsinogen-1 (10-fold greater)

Answer 9

Acute pancreatitis

Question 10

Larger amounts are excreted into urine.

Answer 10

Acute Pancreatitis

Question 11

Trypsin assays are currently being used
for differentiating the cause of _________________?

Answer 11

acute
pancreatitis

Question 12

more
elevated in alcohol-associated pancreatitis

Answer 12

Trypsinogen-2
Trypsin-2-AAT

Question 13

more
elevated in biliary pancreatitis

Answer 13

Trypsinogen-1, AMS & LPS

Question 14

What are the methods of determination of trypsin?

Answer 14

Commercial IMMUNOASSAYS
Urinary trypsinogen-2 test strip

Question 15

Commercial IMMUNOASSAYS detects?

Answer 15

o Trypsinogen-1
o TRY-1
o TRY-1-a1-antitrypsin complex

Question 16

based on the use
of immunochromatography with monoclonal
antibodies.

Answer 16

Urinary trypsinogen-2 test strip