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CLINICAL CHEMISTRY 2 > GGT > Flashcards

GGT Flashcards

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1
Q

What is the systematic name of GGT?

A

E.C. 2.3.2.1

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2
Q

The reaaction of GGT happens at what pH?

A

pH 8.2

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3
Q

What is the mechanism of GGT?

A

GGT Catalyzes the transfer of gamma-glutamyl residue
from gamma-glutamyl peptides to amino acids, other
peptides, or H2O

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4
Q

In decreasing order of abundance, where is GGT found?

A

PRT

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5
Q

The functional unit of kidney

A

Nephron

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6
Q

-
Part of the capillary
-
Filter of the kidney
-
Situated in the Bowman’s capsule

A

Glomerulus

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7
Q

Contains most of our GGT, Liver, Pancreas. Some
amounts of GGT can be found in the intestines.

A

PRT

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8
Q

In chronological order, enumerate the most abundant to least abundant.

A

Proximal Renal Tubules → Liver → Pancreas →
Intestines

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9
Q

What is the half-life of GGT?

A

7-10 days
In alcoholic liver disease: 28 days

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10
Q

What is the main cause of elevated GGT?

A

The problem that originates from the liver.

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11
Q

At what percent does smoking elevate GGT?

A

10%

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12
Q

At what percent does medication elevate GGT?

A

20%

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13
Q

Smoker + alcoholic abuser = elevated GGT

A

Synergy

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14
Q

Most sensitive marker for alcohol intake

A

GGT

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15
Q

In the 1st trimester of pregnancy, at what percentage does it elevate?

A

25%

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16
Q

The increase in GGT in the 1st trimester of pregnancy may reflect changes in
__________________?

A

Liver function + insulin sensitivity.

17
Q

Elevated GGT during 1st trimester may be at risk
of?

A

developing gestational diabetes mellitus.

18
Q

These are synthetic hormones target the liver. Therefore, it
may cause movement activation of many enzymes
not only GGT.

A

Oral contraceptive

19
Q

At what percentage do oral contraceptives elevate GGT?

A

20%

20
Q

What is the primary use of GGT?

A

Evaluation of liver injury

21
Q

Most widely used substrate in GGT analysis

A

Gamma-glutamyl-p-nitroanilide

22
Q

What sample is also preferred aside from none hemolyzed sample?

A

EDTA
BLOOD
PLASMA PREPARED FROM EDTA

23
Q

Why is heparin not a preferred sample?

A

May cause turbidity to the reaction mixture

24
Q

Why is Citrate, Oxalate and Fluoride not a preferred sample?

A

can cause false decrease in the concentration of GGT by about 10- 15%

CLINICAL CHEMISTRY 2 (14 decks)

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