Toxicology: Pharmacology - Heavy metal toxicology Flashcards
1
Q
Five toxic effects of heavy metals
A
- Interfere with function of essential cations
- Cause enzyme inhibition
- Generate oxidative stress
- Alter gene expression
- Perturb cell signalling
2
Q
Five toxic effects of arsenic
A
- CV: shock, arrhythmia
- CNS: encephalopathy, peripheral neuropathy
- Gastroenteritis
- Pancytopaenia
- Cancer
3
Q
Distribution of inorganic oxides and salts of lead
A
> 90% redistributed to skeleton
4
Q
Six toxic effects inorganic oxides and salts of lead
A
- CNS deficits
- Peripheral neuropathy
- Anaemia
- Nephropathy
- HTN
- Reproductive toxicity
5
Q
Toxic effect of organic (tetra-ethyl) lead
A
Encephalopathy
6
Q
Five toxic effects of elemental mercury
A
- CNS: tremor, erethism
- Gingivo-stomatitis
- Peripheral neuropathy
- Acrodynia
- Pneumonitis
7
Q
Three toxic effects of inorganic mercury
A
- ATN
- Gastroenteritis
- CNS effects (rare)
8
Q
Two toxic effects of organic mercury
A
- CNS defects
- Birth defects
9
Q
Chelator for arsenic poisoning
A
Dimercaprol
Succinator
Unithiol
10
Q
Chelator for lead poisoning
A
EDTA
11
Q
Chelator for zinc poisoning
A
EDTA
12
Q
Chelator for manganese poisoning
A
EDTA
13
Q
Chelator for mercury poisoning
A
Unithiol
14
Q
Chelator for copper poisoning
A
Penicillamine
15
Q
Chelator for iron poisoning
A
Deferoxamine
Deferasirox
Deferiprone
