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ACEM Primary Written > Infectious diseases: Pharmacology - Other antimicrobials > Flashcards

Infectious diseases: Pharmacology - Other antimicrobials Flashcards

1
Q

Mechanism of action of chloramphenicol

A

Reversibly binds 50S subunit to inhibit bacterial protein synthesis

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2
Q

Chloramphenicol: bacteriostatic or bactericidal?

A

Bacteriostatic

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3
Q

Coverage of chloramphenicol. What is notably NOT covered?

A

Broad-spectrum: aerobic and anaerobic Gram positives and negatives, Rickettsiae

Does not cover Chlamydiae

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4
Q

Three types of toxicity observed with chloramphenicol use

A
  1. Dose-related suppression of erythropoiesis (reversible)
  2. Aplastic anaemia (irreversible, may be fatal)
  3. “Grey baby syndrome”: vomiting, flaccidity, hypothermia, shock
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5
Q

How is chloramphenicol metabolised and excreted?

A

Hepatic metabolism
Renal excretion

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ACEM Primary Written (150 decks)

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