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ACEM Primary Written > Infectious diseases: Pharmacology - Lincosamides > Flashcards

Infectious diseases: Pharmacology - Lincosamides Flashcards

1
Q

Two examples of lincosamides

A

Lincomycin
Clindamycin

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2
Q

Mechanism of action of lincosamides

A

Reversibly binds ribosomal 50S subunit to inhibit bacterial protein synthesis (at same site as erythromycin)

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3
Q

Are lincosamides bacteriostatic or bactericidal?

A

Both: bactericidal at high concentrations

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4
Q

Indications for clindamycin

A

Skin and soft tissue infections
Toxic shock syndrome*
Necrotising fasciitis*
Prophylaxis against endocarditis in those with valvular heart disease AND penicillin allergy undergoing dental procedures

  • due to inhibition of GAS toxin production
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ACEM Primary Written (150 decks)

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