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ACEM Primary Written > Gastroenterology: Pharmacology - Antispasmodics > Flashcards

Gastroenterology: Pharmacology - Antispasmodics Flashcards

1
Q

Mechanism of action of dicyclomine, hyoscyamine

A

Inhibit muscarinic cholinergic receptors

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2
Q

Mechanism of action of alosetron

A

5HT-3 antagonist: reduces nausea, bloating and pain (via blockage of visceral afferent pain sensation) and increases colonic transit time

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3
Q

Role of 5HT-3 receptors within the GIT

A

Activate visceral afferent pain sensation (nausea, bloating, pain)
Increases colonic motility

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4
Q

Adverse effects of alosetron

A

Constipation
Ischaemic colitis

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ACEM Primary Written (160 decks)

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