Topic 8 Flashcards
Describe a neurone at rest
- outside has a more positive ions so higher charge than inside (polarised)
- Resting potential is about -70mv
How is resting potential created and maintained
- Na/K pumps use active transport to move 3 sodium ions out for every 2 K moved in (ATP)
- K ion channels allow facilitated diffusion out of membrane down conc gradient
Describe permeability at resting
- Not permeable to sodium ions so cannot diffuse back in
2. More positively charged Na ions outside so cerastes electrochemical gradient
What are the 5 steps of an action potential
- Stimulus
- Depolarisation
- repolarsiation
- Hyperpolarisation
- Resting potential
Describe step 1 of action potential (stimulus)
- Excited neurone membrane causing voltage sensitive sodium ion gates to open
- Makes membrane more permeable to sodium so they diffuse in
- Makes inside less negative
Describe Depolarisation (step 2)
- If potential difference reaches threshold of -55mv it causes more sodium ions gates to open
Describe repolarisation
- When potential difference if around +30mv the Na channels close and K channels open causing lots of K ions to diffuse out
- This restores resting potential
Describe Hyperpolarsion
- K ions channels are slow to close so slight overshoot where too much K diffuses out of
Describe step 5 (resting potential)
- Ion channels at rest
2. Sodium-potassium pumps return membrane to resting potential
What is the period where ion channels are recovering called
Refractory period
How does an action potential move along a neurone
- Some Na ions diffuse sideways
- Causes sodium ion channels in next region to open
- Wave of depolarising
- Moves in right direction because can’t fire in refractory period
What is good about refractory periods
- Action potentials don’t overlap so are discrete
2. Unsure unidirectional
How is a bugger stimulus revived
- Action potential always same voltage
2. So will trigger more frequency impulses
How does a local anaesthetic work
- Bind to sodium ion channels
- Prevents Na ions moving in so membrane not depolarised
- No action potential
Describe the Myelin
- Schwann cell
- Insulates axon
- Patches of bare membrane where Na ion channels are concentrated
What’s the gaps between Myelin called
nodes of Ranvier
Describe saltatory conduction
- Depolarisation only happens at noses as that’s where Na ions can get through
- Cytoplasm conducts enough charge to depolarise next node
- Speed called condition velocity
Define a stimulus
A change in internal or external environment
Why can we detect stimulus
- Increases chance of survival
2. By avoiding harmful situations
What detects a stimuli
Receptor cell (or protein on CSM)
What effectors
Cells that bring about a response to stimulus
- Muscle cells
- Glands
How do receptors communicate with effectors
- Nervous or hormonal system
2. Or both
State the 4 steps of a reflex
- Stimulus detected by receptor cells which send electrical impulse down sensory neurone
- Synaptic transmission
- Relay neurone
- CNS processes then sends impulse down motor neurone
Describe the 5 step process of your eye in Bright light
Stimulus: bright light
Receptors: photoreceptors detect bright light
CNS: processes information
Effectors: circular muscles in Iris stimulated by motor neurone
Response: circular muscles contract
What muscles contract in bright/ dim light
Bright: circular
Dim: radial
Define a gland and a hormone
Gland: group of cells specialised to secrete a hormone
Hormone: chemical messengers ( either protein or lipid)
How is a gland stimulated
- By a change in conc of a specific substance
2. Electrical impulse
How do hormones work?
- Diffuse directly into blood from glands
- Transported in circulatory system
- Diffuse out of blood all over body by will on bind to cells with specific receptors found on membrane of target cells
- Triggers response form target cell
Describe how light enters the eye
- Through pupil
- Amount of light controlled by iris
- Focused by Lens into retina (contains photoreceptors)
- Transmits to optic nerve
What is the light-sensitive pigment in Rod cells
Made of retinal and opsin (protein)
Describe Rod cells when unsitumulated (in dark)
- Na+ pumped out of inner segment via a action channel (active)
- Na+ diffuse back into putter segment via cation channels
- Ion movement creates electric current making membrane depolarised
- Triggers the release of neurotransmitters
- Is inhibitory so stops bipolar neurone depolarising to trigger ganglia cell