Tissue Transplants

Question 1

Cross match test

Answer 1

mix recipient’s serum with patients RBC

no clumping = compatible

Question 2

Where are class I MHCs found?

Answer 2

present on all nucleated cells

Question 3

Where are class II MHCs found?

Answer 3

only on APCs

Question 4

Why do you not need to do MHC typing for blood transfusions?

Answer 4

MHCs are not found on RBCs

Question 5

How can rejection occur years after transplant?

Answer 5

some HLAs are not matched and there is always chronic inflammation

this inflammation against minor HLAs finally builds up and rejection occurs

Question 6

Acute rejection is due to …

Answer 6

antibodies to major HLA antigens

alloreactive CD8+ T-cells

Question 7

Hyperacute rejection is due to …

Answer 7

complement activation

pre-exisiting antibodies

Question 8

Chronic rejection is due to …

Answer 8

antibodies to minor HLA antigens

alloantigen specific CD4+ T-cells

Question 9

Timing of hyperacute rejection

Answer 9

minutes to hours

Question 10

Timing of acute rejection

Answer 10

weeks to months