Intro to Renal Function Flashcards

1
Q

Low protein diet effects on BUN ….

A

lowers BUN

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1
Q

BUN

A

blood urea nitrogen

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2
Q

Upper GI bleed …

A

increases BUN

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3
Q

Hypotension w/ low renal perfusion …

A

high BUN

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4
Q

High dose corticosteriod …

A

increases BUN

(induces a catabolic state which breaks down protein into urea )

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5
Q

Tetracycline antibiotics

A

high BUN

induces a catabolic state

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6
Q

What is creatinine dependent on?

A

body mass

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7
Q

OCT

A

secretes creatinine into tubulues

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8
Q

How is creatinine formed?

A

formed from creatine

this is an anabolic process

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9
Q

Anabolic steroids effect on Cr

A

high Cr

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10
Q

LE amputation effect on Cr

A

lower Cr (less muscle mass)

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11
Q

OCT inhibitor

A

High Cr

(cannot secrete creatinine into tubule)

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12
Q

Creatine supplements lead to …

A

transient increases in creatinine

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13
Q

What is the best measure of kidney function?

A

GFR

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14
Q

When can you calculate GFR?

A

only when creatinine is in a steady state

do NOT calculate if creatinine has changed over past couple days

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15
Q

What is the preferred formula for GFR?

A

2021 CKD-EPI formula

16
Q

What is the preferred formula for GFR in children?

A

Schwartz formula

17
Q

How can creatinine be misleading?

A

could look normal but is actually high if they have low muscle mass

18
Q

What can you use to estimate GFR if you cannot use creatinine?

A

cystatin C (best option)

24 hr creatinine clearance (hard to measure)

19
Q

What findings indicate glomerular damage?

A

RBC casts and proteinuria

20
Q

What are the 2 types of glomerular damage?

A

nephritic or nephrotic

21
Q

Nephritic syndrome

A

HTN and proteinuria (but lower than in nephrotic syndrome)

22
Q

Nephrotic syndrome

A

high proteinuria, more edema and hypoalbuminemia

23
Q

Why does nephrotic syndrome cause hypoalbuminemia?

A

nephrotic syndrome has high proteinuria

albumin is the most abundant protein in urine

so, having lots of proteinuria leads to low serum albumin levels

24
Q

Glomerular proteinuria

A

mainly albumin

impairment of glomerular basement membrane

25
Q

Tubular proteinuria

A

impaired reabsorption of proteins

seen in heavy metal poisioning

see low weight proteins in urine

26
Q

Overflow proteinuria

A

mass excretion of low weight proteins

hemoglobinuria, myoglobinuria, etc.

27
Q

Post-renal proteinuria

A

problems below the kidney like inflammation, bleeding and malignancy

28
Q
A