Tissue Homeostasis and Repair Flashcards
Which layer of skin is responsible for cell proliferation?
strata basal
2 examples of permanent cell type
neurons + myocardial cell
permanent cells
always in G0 with no ability to differentiate
stable cells example
hepatocytes
stable cells
in G0 but able to divide if needed
ex: will divide if there is tissue damage
What are 3 ways that tissues can replace mass?
1) regnerate parenchyma
2) fibrosis
3) scarring
Difference between scarring and fibrosis
Fibrosis occurs in response to more chronic inflammation
Scarring occurs in response to acute injury
Similarity between fibrosis and scarring
both lay down connective tissue to replace mass
What 2 cell types can regenerate after tissue damage?
labile and stable
Difference between epidermis and dermis in healing from wound
epidermis can regenerate
dermis scars
example of fibrosis
HCV infection in the liver
chronic inflammation that leads to fibrosis
secondary provisional matrix
granulation tissue
granulation tissue
seen with scarring
lays the groundwork for connective tissue by bringing capillaries to area
what does granulation tissue secrete?
VGEF to make new capillaries
3 stages of liver regeneration
1) initation / priming
2) proliferation
3) termination
priming stage of liver regeneration
increase in growth factors like HGF and EGF
increase in blood flow + cytokines
What growth factor is downregulated during priming?
TGF-B
TGF-B is a negative growth regulator
proliferation stage of liver regeneration
increased proliferation of most cell types in liver
Termination stage of liver regeneration
return to homeostasis
increase in negative growth regualtors like TGF-beta
what is another way to describe liver regeneration?
compensatory hyperplasia
